Susanne Niedermeyer, Martin Eiden, Pavlos Toumazos, Penelope Papasavva‐Stylianou, Ioannis Ioannou, Theodoros Sklaviadis, Cynthia Panagiotidis, Jan Langeveld, A. Bossers, Thorsten Kuczius, Martin Kaatz, Martin H. Groschup, Christine Fast. 2016. Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus. Vet. Res. 47: 99. WOT-01-002-001.01 en WOT-01-002-001.09. DOI: 10.1186/s13567-016-0379-0

Windig, J. J., Hoving, R. A. , Priem, J., Bossers, A., van Keulen, L. J., Langeveld, J. P. 2016. Variation in the prion protein sequence in Dutch goat breeds. J. Anim. Breed. Genet. 133: 366-374. WOT-01-002-001.01 en WOT-01-002-001.09.

Vitale, M., Migliore, S., La Giglia, M., Alberti, P., Di Marco Lo Presti, V., Langeveld, J.P.M. 2016. Scrapie incidence and PRPN polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs. BMC Vet. Res. 12: 141. WOT-01-002-001.01 en WOT-01-002-001.09. DOI 10.1186/s12917-016-0766-9.(BMC Veterinary Research)

Goldmann, W., Marier, E., Stewart, P., Konold, T., Street, S., Langeveld, J., Windl, O., Ortiz-Pelaez, A. 2016. Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. Vet. Rec. 178: 168. Doi:10.1136/vr.103521. WOT-01-002-001.01 en WOT-01-002-001.09

Nadeem, M., Spitzbarth, I., Haist, V., Rohn, K., Tauscher, K., Rohn, K., Bossers, A.,, Langeveld, J., Papasavva-Stylianou, P., Groschup, M. H., Baumgartner, W., Gerhauser, I., Fast, C. 2016. Immunolabelling of non-phosphorylated neurofilament indicates damage of spinal cord axons in TSE-infected goats. Vet. Rec. 178: 141. Doi:10.1136/vr.103425. WOT-01-002-001.01 en WOT-01-002-001.09

Langeveld JPM, Jacobs JG, Hunter N, van Keulen, L.J.M., Lantier, F. van Zijderveld, F.G., and Bossers A.  Prion-type dependent deposition of PRNP-allelic products in heterozygous sheep. J. Virol. January 2016 vol. 90 no. 2 805-812. WOT-01-002-001.01

Hagenaars, T. J., Windig, J. J. 2015. Investigation of a Simple Model for Within-Flock Transmission of Scrapie. PLoS ONE 10 (10): e0139436.

van Keulen LJM, Langeveld JPM, Dolstra CH, Jacobs JG, Bossers A and van Zijderveld F. 2015. TSE strain differentiation in mice by immunohistochemical PrPSc profiles and triplex western blot. Neuropath. Appl. Neurobiol. 41: 756-779. WOT-01-002-001.01

Patricia Aguilar-Calvo, Christine Fast, Kerstin Tauscher, Juan-Carlos Espinosa, Martin H. Groschup, Muhammad Nadeem, Wilfred Goldmann, Jan Langeveld, Alex Bossers, Olivier Andreoletti, and Juan-María Torres. Effect of Q211 and K222 PRNP polymorphic variants in the susceptibility of goats to oral infection with Goat-BSE. J. Infect. Dis. 212: 664-672. WOT-01-002-001.01 en WOT-01-002-001.09

Jan Langeveld. 2014; Enhancing resistance against TSEs by Jan Langeveld; EU Research, Vol: 2014 Issue 2

Hagenaars, T. J. 2014. Control of scrapie by selective breeding: what are we getting for free? Vet. Rec. 174: 528-529 (editorial)

Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, DiBari M, Nonno R, Telling G, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG. 2014. Prion disease tempo determined by host-dependent substrate reduction. J. Clin. Invest. 124: 847-858.

McCutcheon S, Langeveld JPM, Chin Tan B, Gill AC, de Wolf C, Martin S, Gonzalez L, Alibhai J, Alejo-Blanco AR, Campbell L, Hunter N,  Houston EF. 2014. Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity and specificity. PloS ONE 9(2): e91143. doi:10.1371/journal.pone.0091143.

Jan Priem, Jan P.M. Langeveld, Lucien J.M. van Keulen, Fred G. van Zijderveld, Olivier Andreoletti, and Alex Bossers. 2014. Enhanced virulence of sheep-passaged BSE is revealed by decreased polymorphism-barriers in prion protein conversion studies. J.Virol. 88: 2903-2912.

Aguilar-Calvo P, Espinosa JC, Pintado B, Gutiérrez-Adán A, Alamillo E, Miranda A, Prieto I, Bossers A, Andreoletti O, Torres JM. 2014. Role of the goat K222-PrPC polymorphic variant in prion infection resistance. J. Virol. 88: 2670-2676. WOT-01-002-001.01

Zou W-Q, Gambetti PL, Xiao X, Yuan J., Langeveld J, PirisinuL. 2013. Prions in VariablyProtease-Sensitive Prionopathy: An Update. Pathogens 2: 457-471;doi:10.3390/pathogens2030457.

Head MW,Yull H, Ritchie D, Langeveld J, Knight R and Ironside JW. 2013. Variablyprotease sensitive prionopathy in the United Kingdom: A retrospective review1991-2008. Brain 136: 1102–1115.

Tracy Haldiman, Chae Kim, Yvonne Cohen, Wei Chen, JanisBlevins, Liuting Qing, Mark Cohen, Jan Langeveld, Glenn C. Telling, QingzhongKong, and Jiri G. Safar. 2013.Co-existence of Distinct Prion Types Enables Conformational Evolution of HumanPrPSc by Competitive Selection.  J.Biol. Chem. 288: 29846-29861.WOT-01-002-01.01

Xiao X, Yuan J, Haïk S, Cali I, Zhan Y-I, Moudjou M, Li B,Laplanche J-L, Laude H, Langeveld J, Gambetti PL, Kitamoto T, Kong Q, BrandelJP, Cobb BA, Petersen RB, Zou WQ. Glycoform-selective prion formation in sporadic and familial forms ofprion disease. PLoS ONE 8(3): e58786. Doi:10.1371/journal.pone.0058786.

DiBari MA, Nonno R, Castilla J, D’Agnostino C, Pirisinu L,Riccardi G, Conte M, Richt J, Langeveld J, Vaccari G, Agrimi U. Chronic WastingDisease in bank voles. Characterisationof the shortest incubation time model for prion diseases. PLoS Pathog.9(3): e1003219. doi 10.1371/journal. ppat.1003219.

M. Kadohira, M. A. Stevenson, H. R. Høgåsen and A. deKoeijer. 2012. A QuantitativeRisk Assessment for Bovine Spongiform Encephalopathy in Japan. RiskAnal. 32: 2198-2208.

Daniela Meloni, Aart Davidse, Jan P. M. Langeveld, KatiaVarello, Cristina Casalone, Cristiano Corona, Anne Balkema-Buschmann, Martin H.Groschup, Francesco Ingravalle, Elena Bozzetta. 2012. EU-Approved Rapid Tests for bovinespongiform encephalopathy detect atypical forms: a study for their sensitivities.PLoS One 9: e43133

Filali H., , Martin-Burriel, I., Harders, F., Varona, L., Serrano, C.,Acín, C., Badiola J.J., Bossers, A., Bolea., R. 2012. Medullaoblongata transcriptome changes during presymptomatic natural scrapie and theirassociation with prion-related lesions. BMC Genomics 13:399.

Moda F, Suardi S; Di Fede G; Vimercati C; Ruggerone M;Campagnani I; Fociani P; Langeveld, J; Terruzzi A; Zerbi P, Bishop M; Manson J;Will RG; Limido L. 2012. MM2-thalamicCreutzfeldt-Jakob disease: neuropathological, biochemical and transmissionstudies identify a distinctive prion strain. Brain Pathol. 22:662-669.

Tang Y, Gielbert A, Jacobs JG, Baron T, Andreoletti O,Yokoyama T, Langeveld JP, Sauer MJ. 2012.All major prion types recognised by a multipleximmunofluorometric assay for disease screening and confirmation in sheep. J. Immunol. Meth. 380: 30-39.

Bannach O, Birkmann E, Reinartz E, Jaeger K-E, Langeveld JPM, Rohwer, RG,Gregori, L, Terry LA, Willbold D and Riesner D. 2012 Detection of PrionProtein Particles in Blood Plasma of Scrapie Infected Sheep. PLoS One 7(5): e36620.doi:10.1371/journal.pone.0036620

Jacobs JG, Bossers A,Rezaei H, van Keulen LJM, McCutcheon S, Sklaviadis T, Lantier I, Berthon P,Lantier F, van Zijderveld FG, Langeveld JPM. Proteinase K resistant materialin ARR/VRQ sheep brain affected with classical scrapie is composed mainly ofVRQ prion protein. J. Virol. 85: 12537-12546. BAS nrs. WOT-01-002-001.01 andWOT-01-002-001.05

Moore J, Hawkins SAC, Austin AR, Konold T, Green RB, Blamire IW, Dexter I,Stack MJ, Chaplin MJ, Langeveld JPM, Simmons M, Spencer YI, Webb PR1, Dawson M,Wells GAH, Studies of the transmissibilityof the agent of bovine spongiform encephalopathy to the domestic chicken. BMC Res Notes 4: 501.

Nodelijk, G, vanRoermund H, van Keulen L, Engel B, Vellema P, and Hagenaars T. Breeding with resistant ramsleads to rapid control of scrapie in affected flocks. Vet. Res. 42: 5.

Wilfred Goldmann, Kelly Ryan, Paula Stewart, David Parnham, RosaXicohtencatl, Nora Fernandez, Ginny Saunders, Otto Windl, Lorenzo Gonzalez,Alex Bossers and James Foster. Caprine prion genepolymorphisms are associated with decreased incidence of classical scrapie ingoat herds in the United Kingdom. Vet. Res. 42: 110.

Melchior, M.B.,Hagenaars, T.J., Davidse, A., van Keulen, L.J.M., Bossers, A., en vanZijderveld, F.G.Acht jaar actieve scrapie surveillance in Nederland: heteffect van het fokprogramma op de prevalentie van scrapie bij het schaap(2002-2010). Tijdschr. Diergeneeskd. 136: 84-93. Project BAS nrsWOT-01-002-001.01, WOT-01-002-001.07

Langeveld JPM, Erkens JHF, Rammel I,Jacobs JG, Davidse A, van Zijderveld F, Bossers A, and Schildorfer H. 2011. Four Independent Molecular Prion ProteinParameters for Discriminating New Cases of C, L, and H Bovine SpongiformEncephalopathy in Cattle. J. Clin. Microbiol.49: 3026-3028. Project BAS nr: WOT-01-002-001.01.

Kuczius T, Brandstädter L, Karch H, Langeveld JPM.2011. A duplex approach for immunochemicalstaining and typing of protein in western blots. Anal. Biochem. 409: 260-266

Jacobs JG, Sauer M, van Keulen LJM, Tang Y, Bossers A, and Langeveld JPM. 2011. Differentiation ofruminant TSE isolate types, including BSE and CH1641 scrapie. J. Gen. Virol. 92: 222-232

Alan Rigter, Jan P.M. Langeveld, Fred G. van Zijderveld and Alex Bossers. 2010. Prion Protein Self Interactions; agateway to novel therapeutic strategies? Vaccine 28: 7810-7823.

Hoffmann C, Eiden M, Kaatz M, Keller M, Ziegler U,Rogers R, Hills B, Balkema-Buschmann A, van Keulen L, Jacobs JG, Groschup MH. BSE infectivity injejunum, ileum and ileocaecal junction of incubating cattle. Vet. Res. 42: 21. Project BAS nr: WOT-01-002-001.01.

Polak MP, Larska M, Langeveld JPM, Buschmann A, Groschup MH, Zmudzinski JF.(2010). Diagnosis of the firstcases of scrapie, an atypical variant, in Poland. Vet. J. 186: 47-52.

González L., Sisó S., Monleón E., Casalone C., van Keulen LJM.,Balkema-Buschmann A., Ortiz-Peláez A., Iulini B., Langeveld JPM., Hoffmann C.,Badiola.JJ., Jeffrey M., and Acín C. (2010) Variability in diseasephenotypes within a single PRNP genotype suggests the existence of multiplenatural sheep scrapie strains within Europe</L>. J. Gen. Virol. 91: 2630-2641.

Bouzalas I,Lörtscher F, Dovas C, Oevermann A, Langeveld JPM, Papanastassopoulou M,Papadopoulos O, Zurbriggen A, and Seuberlich A distinct proteinase K resistantprion protein fragment in goats with no signs of disease in a classical scrapieoutbreak. J. Clin. Microbiol. 49:2109-2115. Project BAS nr: WOT-01-002-001.01

Hicham Filali,Inmaculada Martin-Burriel, Frank Harders, Luis Varona, Jaber Lyahyai, PilarZaragoza, Martí Pumarola, Juan J Badiola, Alex Bossers, Rosa Bolea. Gene expression profiling andassociation with prion-related lesions in the medulla oblongata of symptomaticnatural scrapie animals. PLosOne 6(5):e19909. doi:10.1371/journal.pone. 0019909. Project BAS nr: WOT-01-002-001.01

Pirisinu, L., DiBari M, Marcon S, Vaccari G, D’Agostino C, Fazzi P, Esposito E, Cardone F,Langeveld J, Agrimi U, Nonno R. (2010) A New Method for theCharacterization of Strain-Specific Conformational Stability ofProtease-Sensitive and Protease-Resistant PrPSc. PLoS ONE 5 (9): e12723.

Zou W-Q, Puoti G, Xiao X, Yuan J, Qing, L., Cali I, Shimoji M, Langeveld JPM,Castellani R, Notari S, Crain, B., , Schmidt RE, Geschwind M, DeArmond SJ,Cairns N, Dickson, D, Honig L, Torres, JM, Mastrianni, J, Capellari S, GiacconeG, Belay ED, Schonberger LB, Cohen, M, Perry, G, Kong Q, Parchi P, TagliaviniF, Gambetti P. (2010). Protease-Sensitive Prionopathy: ANew Sporadic Disease of the Prion Protein. Ann. Neurol. 68: 162-172.

Marielle B Melchior, Jack J Windig, Thomas J Hagenaars, Alex Bossers, AartDavidse and Fred G Zijderveld van. (2010). Eradication of scrapiewith selective breeding: are we nearly there?. BMC Vet. Res. 6: 24.

Dobly A, Langeveld J, Rodeghiero C, Durand S, Geeroms R, vanMuylem P, deSloovere J, Vanopdenbosch E, Roels S. (2010) No H- and L-type cases in Belgium incattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging sevenyears and older. BMC Vet. Res. 6:26;doi:10.1186/1746-6148-6-26.

Thomas J. Hagenaars, Marielle B. Melchior, Alex Bossers, Aart Davidse, Fred G.van Zijderveld. (2010). Scrapie incidence in sheep ofsusceptible genotype is declining in a population subject to breeding forresistance. BMC Vet. Res. 6: 25.

Zou, W-Q, Langeveld J, Xiao X., Chen S, McGeer PL, Yuan J, Payne MC, Kang H-E,McGeehan JM, Sy M-S,Greenspan NS, Kaplan D, Wang G-X, Parchi P, Hoover E,Kneale G, Telling G, Surewicz W, Kong Q, Guo J-P. (2010). PrP conformational translationsalter species-preference of a PrP specific antibody. J. Biol. Chem. 285: 13874-13884.

Yue Tang, Jemma Thorne, Kirsty Whatling, Jorg Jacobs, Jan Langeveld and MauriceSauer. (2010). A single step multipleximmunofluorometric assay for differential diagnosis of BSE and scrapie. J. Immunol. Meth. 356:29–38.

Christina D. Orru, Jason M. Wilham, Andrew G. Hughson, Lynne D. Raymond,Kristin L. McNally, Alex Bossers, Ciriaco Ligios and Byron Caughey. Human variantCreutzfeldt–Jakob disease and sheep scrapie PrPres detection using seededconversion of recombinant prion protein. Protein Engineering, Design & Selection vol. 22 no. 8 pp. 515–521,2009

Rigter A, PriemJ, Timmers-Parohi D, Langeveld JP, van Zijderveld FG, Bossers A. Prion protein self-peptides modulateprion interactions and conversion. BMC Biochem. 2009 Nov 30;10:29

Cali I,Castellani R, Alshekhlee A, Cohen Y, Blevins J, Yuan J, Langeveld JP, Parchi P,Safar JG, Zou WQ, Gambetti P. Co-existence of scrapieprion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effecton the phenotype and prion-type characteristics. Brain. 2009 Oct;132(Pt 10):2643-58.

Parchi P,Strammiello R, Notari S, Giese A, Langeveld JP, Ladogana A, Zerr I, RoncaroliF, Cras P, Ghetti B, Pocchiari M, Kretzschmar H, Capellari S. Incidence and spectrum of sporadicCreutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence ofPrPSc types: an updated classification. Acta Neuropathol. 2009 Nov;118(5):659-71

Polak MP, LarskaM, Langeveld JP, Buschmann A, Groschup MH, Zmudzinski JF. Diagnosis of the first cases ofscrapie in Poland. Vet J. 2009 Aug26.

Rigter A, PriemJ, Timmers-Parohi D, Langeveld JP, Bossers A. Mapping functional prion-prionprotein interaction sites using prion protein based peptide-arrays. Methods Mol Biol. 2009;570:257-71.

GabrieleVaccari, Cynthia H. Panagiotidis, Cristina Acin, Simone Peletto, FrancisBarillet, Pierluigi Acutis, Alex Bossers, Jan Langeveld,Lucien van Keulen,Theodoros Sklaviadis, Juan J. Badiola, Olivier Andréoletti, Martin H. Groschup,Umberto Agrimi, James Foster, Wilfred Goldmann. State-of-the-art review of goat TSEin the European Union, with special emphasis on PRNP genetics and epidemiology. Vet. Res. (2009) 40:48

Acutis PL,Colussi S, Santagada G, Laurenza C, Maniaci MG, Riina MV, Peletto S, GoldmannW, Bossers A, Caramelli M, Cristoferi I, Maione S, Sacchi P, Rasero R (2008). Genetic variability of the PRNPgene in goat breeds from Northern and Southern Italy. J Appl Microbiol. 104(6):1782-9

Brandel JP,Heath CA, Head MW, Levavasseur E, Knight R, Laplanche JL, Langeveld JP,Ironside JW, Hauw JJ, Mackenzie J, Alpérovitch A, Will RG, Haïk S. Variant Creutzfeldt-Jakob disease inFrance and the United Kingdom: Evidence for the same agent strain. Ann Neurol. 2009 Mar;65(3):249-56.

van Keulen LJ, BossersA, van Zijderveld F. (2008). TSEpathogenesis in cattle and sheep. Vet Res. 39(4):24.

van Keulen LJ, Vromans ME, Dolstra CH, Bossers A, vanZijderveld FG (2008). Pathogenesis of bovine spongiform encephalopathy insheep. Arch Virol. 153(3):445-53.

Canello, T.; Engelstein, R.; Moshel, O.; Xanthopoulos,K.; Langeveld, J.P.M.; Sklaviadis, T.; Gasset, M.; Gabizon, R. (2008).Methionine Sulfoxides onPrPSc: A Prion-Specific Covalent Signature. Biochemistry 47 (34). - p. 8866 - 8873.

Gavier-Widen,D.; Noremark, M.; Langeveld, J.P.M.; Stack, M.; Biacabe, A.G.; Vulin, J.;Chaplin, M.; Richt, J.A.; Jacobs, J.G.; Acin, C.; Monleón, E.; Renström, A.;Klingeborn, B.; Baron, T.G.M. (2008). Bovine spongiformencephalopathy in Sweden: an H-type variant. Journal of Veterinary Diagnostic Investigation 20 (1). - p. 2 - 10.

Notari, S.;Strammiello, R.; Capellari, S.; Giese, A.; Cescatti, M.; Grassi, J.; Ghetti,B.; Langeveld, J.P.M.; Zou, W.Q.; Gambetti, P.; Kretzschmar, H.A.; Parchi, P.(2008). Characterization ofTruncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease. Journal of Biological Chemistry 283 (45). - p. 30557 - 30565.

Polak, M.P.;Zmudzinski, J.F.; Jacobs, J.G.; Langeveld, J.P.M. (2008). Atypical status of bovinespongiform encephalopathy in Poland: a molecular typing study. Archives of Virology 153 (1). - p. 69 - 79.

Uro-Coste, E.;Cassard, H.; Simon, S.; Lugan, S.; Bilheude, J.M.; Perret-Liaudet, A.;Ironside, J.E.; Haik, S.; Basset-Leobon, C.; Lacroux, C.; Peoch, K.;Streichenberger, N.; Langeveld, J.P.M.; Head, M.W.; Grassi, J.; Hauw, J.J.;Schelcher, F.; Delisle, M.B.; Andreoletti, O. (2008). Beyond PrPres type 1/Type 2 dichotomyin Creutzfeldt-Jakob disease. PLoS Pathogens 4 (3). - p. e1000029.

Haïk S, Peyrin JM, Lins L, Rosseneu MY, Brasseur R,Langeveld JP, Tagliavini F, Deslys JP, Lasmézas C, Dormont D. Neurotoxicity of the putativetransmembrane domain of the prion protein. Neurobiol Dis. 2000 Dec;7

Biacabe, A.G.;Jacobs, J.G.; Bencsik, A.; Langeveld, J.P.M.; Baron, T.G.M. (2007). H-type bovine spongiformencephalopathy-complex molecular featrues and similarities with some humanprion diseases. Prion 1 (1). -p. 61 - 68.

Espinosa, J.C.;Andreoletti, O.; Castilla, J.; Herva, M.E.; Morales, M.; Alamillo, E.;San-Segundo, F.D.; Lacroux, C.; Lugan, S.; Salguero, F.J.; Langeveld, J.P.M.;Torres, J.M. (2007). Sheep-passaged bovinespongiform encephalopathy agent exhibits altered pathobiological properties inbovine-PrP transgenic mice. Journal ofVirology 81 (2). - p. 835 - 843.

Jacobs, J.G.;Langeveld, J.P.M.; Biacabe, A.G.; Acutis, P.L.; Polak, M.P.; Gavier-Widen, D.;Buschmann, A.; Caramelli, M.; Casalone, C.; Mazza, M.; Groschup, M.; Erkens,J.H.F.; Davidse, A.; Zijderveld, F.G. van; Baron, T. (2007). Molecular discriminationof atypical bovine spongiform encephalopathy strains from a geographical regionspanning a wide area in Europe. Journal of Clinical Microbiology 45 (6). - p. 1821 - 1829.

Notari, S.;Capellari, S.; Langeveld, J.P.M.; Giese, A.; Strammiello, R.; Gambetti, P.;Kretzschmar, H.A.; Parchi, P. (2007). Arefined method for molecular typing reveals that co-occurrence of PrPSc typesin Creutzfeldt-Jakob disease is not the rule. Laboratory Investigation 87 (11). - p. 1103 - 1112.

Rigter, A.;Langeveld, J.P.M.; Timmers-Parohi, D.; Jacobs, J.G.; Moonen, P.L.J.M.; Bossers,A. (2007). Mapping of possible prionprotein self interaction domains using peptide arrays. Biochemistry 8 . - p. 6.

Meade-White K,Race B, Trifilo M, Bossers A, Favara C, Lacasse R, Miller M, Williams E,Oldstone M, Race R, Chesebro B. Resistance to chronicwasting disease in transgenic mice expressing a naturally occurring allelicvariant of deer prion protein. J Virol. 2007 May;81(9):4533-9.

Lima, A.B.C., A.Bossers, C.E.A. Souza, S.M.P. Oliveira, S.L.T. Santiago and D.M. Oliveira.(2007). PrP genotypes in a pedigree flock ofSanta Inês sheep. VeterinaryRecord 160:336-337.

Baron, T.G.M.;Biacabe, A.G.; Bencsik, A.; Langeveld, J.P.M. (2006). Transmission of new bovine prion tomice. Emerging Infectious Diseases 12 (7). - p. 1125 -1128.

Biswas, S.;Langeveld, J.P.M.; Tipper, D.; Lu, S. (2006). Intracellularaccumulation of a 46 kDa species of mouse prion protein as a result of loss ofglycosylation in cultured mammalian cells. Biochemical and Biophysical Research Communications 349 (1). - p. 153 -161.

Gretzschel, A.;Buschmann, A.; Langeveld, J.P.M.; Groschup, M.H. (2006). Immunologicalcharacterization of abnormal prion protein from atypical scrapie cases in sheepusing a panel of monoclonal antibodies. Journal of General Virology 87 . - p. 3715 - 3722.

Jeffrey, M.;Martin, S.; Gonzalez, L.; Foster, J.; Langeveld, J.P.M.; Zijderveld, F.G. van;Grassi, J.; Hunter, N. (2006). Immunohistochemicalfeatures of Prp(d) accumulation in natural and experimental goat transmissiblespongiform encephalopathies. Journal of ComparativePathology 134 (2-3). - p. 171 - 181.

Langeveld, J.P.M.; Jacobs, J.G.; Erkens, J.H.F.;Bossers, A.; Zijderveld, F.G. van; Keulen, L.J.M. van (2006). Rapid and discriminatorydiagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep. BMC Veterinary Research 2 (19).

Hunter, N., andBossers, A. (2006). The PrP genotype as a marker forscrapie susceptibility in sheep. In: PRIONS in humans and animals. Eds: Hörnlimann, Riesner and Kretzschmar. Berlin. p640-647.

Raymond, G.J.;Olsen, E.A.; Lee, K.S.; Raymond, L.D.; Bryant, P.K.; Baron, G.S.; Caughey,W.S.; Kocisko, D.A.; McHolland, L.E.; Favara, C.; Langeveld, J.P.M.;Zijderveld, F.G. van; Mayer, R.T.; Miller, M.W.; Williams, E.S.; Caughey, B.(2006). Inhibition ofprotease-resistant prion protein formation in a transformed deer cell lineinfected with chronic wasting disease. Journal of Virology 80 (2). - p. 596 - 604.

Yull, H.M.;Ritchie, D.L.; Langeveld, J.P.M.; Zijderveld, F.G. van; Bruce, M.E.; Ironside,J.W.; Head, M.W. (2006). Detectionof type 1 prion protein in variant Creutzfeldt-Jakob disease. American Journal of Pathology 168 (1). - p. 151 - 157.

Acutis PL, A.Bossers, J. Priem, M.V. Riina, S. Peletto, M. Mazza, C. Casalone, G. Forloni,G. Ru, M. Caramelli (2006). Identification of prion protein genepolymorphisms in goats from Italian scrapie outbreaks. Journal of General Virology 87:1029-23.

Sharpe, A.;McElroy, M.; Langeveld, J.P.M.; Bassett, H.; O'Donoghue, A.M.; Sweeney, T.(2005). Immunohistochemical studies ofscrapie archival material from Irish ARQ/ARQ sheep for evidence of bovinespongiform encephalopathy-derived disease. Research in Veterinary Science 79 (1). - p. 29 - 35.

Rigter, Alan andAlex Bossers (2005). Sheep scrapiesusceptibility-linked polymorphisms do not modulate the initial binding ofcellular to disease-associated prion protein prior to conversion. J. Gen. Virol. 86:2627-2634.

Thuring, C.M.A.; Keulen, L.J.M. van; Langeveld,J.P.M.; Vromans, M.E.W.; Zijderveld, F.G. van; Sweeney, T. (2005). Immunohistochemical distinctionbetween preclinical bovine spongiform encephalopathy and scrapie infection insheep. Journal of ComparativePathology 132 (1). - p. 59- - 69.

Veerhuis, R.;Boshuizen, R.S.; Morbin, M.; Mazzoleni, G.; Hoozemans, J.J.; Langedijk, J.P.; Tagliavini,F.; Langeveld, J.P.M.; Eikelenboom, P. (2005). Activationof human microglia by fibrillar prion protein-related peptides is enhanced byamyloid-associated factors SAP and C1q. Neurobiology of Disease 19 (1-2). - p. 273 - 282.

Acutis P.L.,Sbaiz L., Verburg F., Riina.M.V., Ru. G., Moda G., Caramelli M., Bossers A. Low level of the scrapieresistance-associated allele and presence of lysine-171 allele of the prionprotein gene in Italian Biellese ovine breed. J. General Virology. June 2004.

Bate, C.;Langeveld, J.P.M.; Williams, A. (2004). Manipulationof PrPres production in scrapie-infected neuroblastoma cells. Journal of Neuroscience Methods 138 (1-2). - p. 217 - 223.

Boshuizen, R.S.; Langeveld, J.P.M.; Salmona, M.;Williams, A.; Meloen, R.H.; Langendijk, J.P. (2004). An in vitro screening assay based onsynthetic prion protein peptides for identification of fibril-interferingcompounds. Analytical Biochemistry 333(2). - p. 372 - 380.

Sachsamanoglou,M.; Paspaltzis, I.; Petrakis, S.; Verghese-Nikolakaki, S.; Panagiotidis, C.H.;Voitlander, T.; Budka, H.; Langeveld, J.P.M.; Sklaviadis, T. (2004). Antigenicprofile of human recombinant PrP: generation and chracterization of a versatilepolyclonal antiserum. Journal ofNeuroimmunology 146 (1). - p. 22 - 32.

Thuring, C.M.A.;Erkens, J.H.F.; Jacobs, J.G.; Bossers, A.; Keulen, L.J.M. van; Garssen, G.J.;Zijderveld, F.G. van; Ryder, S.J.; Groschup, M.H.; Sweeney, T.; Langeveld,J.P.M. (2004). Discrimination betweenscrapie and bovine spongiform encephalopathy in sheep by molecular size,immunoreactivity, and glycoprofile of prion protein. Journal of Clinical Microbiology 42 (3). - p. 972 - 980.

Langeveld, J.P.M.; Wang, J.J.; Wiel, D.F.M. van de;Shih, G.C.; Garssen, G.J.; Bossers, A.; Shih, J.C.H. (2003). Enzymatic degradation ofprion protein in brain stem from infected cattle and sheep. Journal of Infectious Diseases 188 (11). - p. 1782 - 1789.

Bossers, A.,Rigter, A., de Vries, R., and Smits, M.A. (2003). In vitro conversion of normal PrP topathological isoforms of PrP. Invited review in: Prion Diseases. Clinics in Laboratory Medicine23:227-247. Editor. B. Ghetti., Piccardo P., and Schmidt R..

Bate, C.;Boshuizen, R.S.; Langeveld, J.P.M.; Williams, A. (2002). Temporaland spatial relationship between the death of PrP-damaged neurones andmicroglial activation. NeuroReport 13(13). - p. 1695 - 1700.

Sigurdson, C.J.;Barillas-Mury, C.; Miller, M.W.; Oesch, B.; Keulen, L.J.M. van; Langeveld,J.P.M.; Hoover, E.A. (2002). PrPCWDlymphoid cell targets in early and advanced chronic wasting disease of muledeer. Journal of General Virology 83 (10). - p. 2617 - 2628.

Veerhuis, R.; Hoozemans, J.J.M.; Janssen, I.;Boshuizen, R.S.; Langeveld, J.P.M.; Eikelenboom, P. (2002). Adult human microglia secretecytokines when exposed to neurotoxic prion protein peptide: no intermediaryrole for prostaglandin E-2. Brain research925, 195-203. - ISSN 0006-8993

Garssen, G.J.;Keulen, L.J.M. van; Farquhar, C.F.; Smits, M.A.; Jacobs, J.G.; Bossers, A.;Meloen, R.H.; Langeveld, J.P.M. (2000). Applicability of three anti-PrPpeptide sera including staining of tonsils and brainstem of sheep with scrapie. Microscopy research and technique 50, 2000, 32-39

Keulen, L.J.M. van; Langeveld, J.P.M.; Garssen, G.J.;Jacobs, J.G.; Schreuder, B.E.C.; Smits, M.A. (2000). Diagnosis of bovinespongiform encephalopathy: a review. Veterinary quarterly 22, 2000, 197-199

Keulen, L.J. van; Schreuder, B.E.; Vromans, M.E.;Langeveld, J.P.; Smits, M.A. (2000). Pathogenesis of natural scrapie insheep. Archives of Virology,Supplement, 57-71

Alex Bossers,Ruth de Vries, and Mari A. Smits (2000). Susceptibility of sheep for scrapieas assessed by in vitro conversion of nine natural occurring variants of PrP. Journal of Virology vol 74 no 3 p 1407-1414.

Keulen, L.J.M. van; Schreuder, B.E.C.; Vromans,M.E.W.; Langeveld, J.P.M.; Smits, M.A. (1999).Scrapie-associated prion protein inthe gastro-intestinal tract of sheep with natural scrapie. Journal comparative pathology 121, 1999, 55-63

Alex Bossers,Frank L. Harders, and Mari A. Smits. (1999). PrP genotype frequencies of the mostdominant sheep breed in a country free from scrapie. Archives of Virology 144:829-834.

Roels, S.; Vanopdenbosch, E.; Langeveld, J.P.M.;Schreuder, B.E.C. (1999). Immunohistochemicalevaluation of tonsillar tissue for preclinical screening of scrapie based onsurveillance in Belgium. Veterinaryrecord 145, 1999, 524-525

Rubenstein, R.;Kascsak, R.J.; Papini, M.; Kascsak, R.; Carp, R.I.; LaFauci, G.; Meloen, R.;Langeveld, J.P.M. (1999). Immune surveillance and antigenconformation determines humoral immune response to the prion protein immunogen. Journal of neurovirology 5, 1999, 401-413

Lo-Man, R.;Langeveld, J.P.M.; Martineau, P.; Hofnung, M.; Meloen, R.H.; Leclerc, C.(1998). Immunodominance does notresult from peptide competition for MHC class II presentation. Journal of immunology 160, 1998, 1759-1766

Piccardo, P.;Langeveld, J.P.M.; Hill, A.F.; Dlouhy, S.R.; Young, K.; Giaccone, G.; Rossi,G.; Bugiani, O.; Meloen, R.H.; Colling, J.; Tagliavini, F. (1998). An antibody raised against aconserved sequence of the prion protein recognizes pathological isoforms inhuman and animal prion diseases, including Creutzfeldt-Jakob disease and bovinespongiform encephalopathy. Americanjournal of pathology 152, 1998, 1415-1420

Schreuder,B.E.C.; Keulen, L.J.M. van; Vromans, M.E.W.; Langeveld, J.P.M.; Smits, M.A.(1998). Tonsillar biopsy and PrPSc detectionin the preclinical diagnosis of scrapie. Veterinary record 142, 1998, 564-568

Schreuder, B.E.C.; Keulen, L.J.M. van; Smits, M.A.;Langeveld, J.P.M.; Stegeman, J.A. (1997). Control of srapie eventuallypossible?. Veterinary quarterly 19,1997, 105-113

G.J. Raymond, J.Hope, D.A. Kocisko, S.A. Priola, L.D. Raymond, A. Bossers, J. Ironside, R.G.Will, S.G. Chen, R.B. Petersen, P. Gambetti, R. Rubenstein, M.A. Smits, P.T.Lansbury Jr, and B. Caughey. (1997). Molecular assessment of thepotential transmissibilities of BSE and scrapie to humans. Nature 388:285-288.

Alex Bossers,Peter B.G.M. Belt, Gregory J. Raymond, Byron Caughey, Ruth de Vries, and MariA. Smits. (1997). Scrapie susceptibility-linkedpolymorphisms modulate the in vitro conversion of sheep prion protein toprotease-resistant forms. Proc. Natl.Acad. Sci. USA 94:4931-4936.

M.A. Smits, A.Bossers, and B.E.C. Schreuder. (1997). Prion protein and scrapiesusceptibility. VeterinaryQuartely 19:101-105.

Alex Bossers,Bram E.C. Schreuder, Ida H. Muileman, Peter B.G.M. Belt, and Mari A. Smits.(1996). PrP genotype contributesto determining survival times of sheep with natural scrapie. Journal of General Virology 77:2669-2673.

Keulen, L.J.M. van; Schreuder, B.E.C.; Meloen, R.H.;Mooij-Harkes, G.; Vromans, M.E.W.; Langeveld, J.P.M. (1996). Immunohistochemical detection ofprion protein in lymphoid tissues of sheep with natural scrapie. Journal clinical microbiology 34, 1996, 1228-1231

Schreuder, B.E.C.; Keulen, L.J.M. van; Vromans,M.E.W.; Langeveld, J.P.M.; Smits, M.A. (1996). Preclinicaltest for prion diseases. Nature 381, 1996, 563

Keulen, L.J.M.; Schreuder, B.E.C.; Meloen, R.H.;Poelen-van der Berg, M.; Mooij-Harkes, G.; Vromans, M.E.W.; Langeveld, J.P.M.(1995). lmmunohistochemical detection andlocalization of prion protein in brain tissue of sheep with natural scrapie. Veterinary pathology 32, 1995, 299-308