Publicaties/publications ziekte van Aujeszky

van Rooij EM, Rijsewijk FA, Moonen-Leusen HW, Bianchi AT, Rziha HJ.; Comparison of different prime-boost regimes with DNA and recombinant Orf virus based vaccines expressing glycoprotein D of pseudorabies virus in pigs. Vaccine. 2010 Feb 17;28(7):1808-13. Epub 2009 Dec 16.

Kroese, M.V., Zevenhoven-Dobbe, J.C., Bos-de Ruijter, J.N., Peeters, B.P., Meulenberg, J.J., Cornelissen, L.A. and Snijder, E.J. The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis. (2008) J Gen Virol. 89:494-499.

van Rooij EM, Moonen-Leusen HW, de Visser YE, Middel WG, Boersma WJ, Bianchi AT.; A DNA vaccine coding for gB and gD of pseudorabies virus (suid herpes type 1) primes the immune system in the presence of maternal immunity more efficiently than conventional vaccines; Vaccine. 2006 Feb 27;24(9):1264-73. Epub 2005 Oct 3.

van Rooij EM, de Bruin MG, de Visser YE, Middel WG, Boersma WJ, Bianchi AT.; Vaccine-induced T cell-mediated immunity plays a critical role in early protection against pseudorabies virus (suid herpes virus type 1) infection in pigs; Vet Immunol Immunopathol. 2004 May;99(1-2):113-25.

van Rooij EM, Glansbeek HL, Hilgers LA, te Lintelo EG, de Visser YE, Boersma WJ, Haagmans BL, Bianchi AT.; Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant; J Virol. 2002 Oct;76(20):10540-5.

Van Nes A, De Jong MC, Kersten AJ, Kimman TG, Verheijden JH. An analysis of a presumed major outbreak of pseudorabies virus in a vaccinated sow herd. Epidemiol Infect. 2001 Feb;126(1):119-28.

Wagenaar F, Pol JM, de Wind N, Kimman TG. Deletion of the UL21 gene in Pseudorabies virus results in the formation of DNA-deprived capsids: an electron microscopy study.Vet Res. 2001 Jan-Feb;32(1):47-54.

De Bruin MG, Samsom JN, Voermans JJ, van Rooij EM, De Visser YE, Bianchi AT. Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus. Vet Immunol Immunopathol. 2000 Aug 31;76(1-2):125-35.

de Bruin TG, van Rooij EM, de Visser YE, Voermans JJ, Samsom JN, Kimman TG, Bianchi AT. Discrimination of different subsets of cytolytic cells in pseudorabies virus-immune and naive pigs. J Gen Virol. 2000 Jun;81(Pt 6):1529-37.

van Rooij EM, Haagmans BL, Glansbeek HL, de Visser YE, de Bruin MG, Boersma W, Bianchi AT; A DNA vaccine coding for glycoprotein B of pseudorabies virus induces cell-mediated immunity in pigs and reduces virus excretion early after infection; Vet Immunol Immunopathol. 2000 Apr 19;74(1-2):121-36.

A.A. de Koeijer, A. Stegeman. (2000) Terminating Aujeszky vaccination in the Netherlands? Veterinary Research 31 (1) 160-161

Haagmans BL, van Rooij EM, Dubelaar M, Kimman TG, Horzinek MC, Schijns VE, Bianchi AT. Vaccination of pigs against pseudorabies virus with plasmid DNA encoding glycoprotein D.Vaccine. 1999 Mar 5;17(9-10):1264-71.

van Rooij EM, Haagmans BL, de Visser YE, de Bruin MG, Boersma W, Bianchi AT; Effect of vaccination route and composition of DNA vaccine on the induction of protective immunity against pseudorabies infection in pigs; Vet Immunol Immunopathol. 1998 Nov 24;66(2):113-26.

De Bruin MG, De Visser YE, Kimman TG, Bianchi AT. Time course of the porcine cellular and humoral immune responses in vivo against pseudorabies virus after inoculation and challenge: significance of in vitro antigenic restimulation. Vet Immunol Immunopathol. 1998 Sep 16;65(1):75-87.

Bianchi AT, Moonen-Leusen HW, van Milligen FJ, Savelkoul HF, Zwart RJ, Kimman TG. A mouse model to study immunity against pseudorabies virus infection: significance of CD4+ and CD8+ cells in protective immunity. Vaccine. 1998 Oct;16(16):1550-8..

Boersma WJ, Van Rooij EM, Scholten JW, Zwart RJ, Kimman TG, Bianchi A. Silent memory induction in maternal immune young animals. Vet Q. 1998;20 Suppl 3:S89-92.

Bouma A, De Jong MD, Kimman TG. The influence of maternal immunity on the development of the in vitro lymphocyte proliferation response against pseudorabies virus in pigs. Res Vet Sci. 1998 Mar-Apr;64(2):167-71.

de Bruin MG, van Rooij EM, Voermans JJ, de Visser YE, Bianchi AT, Kimman TG. Establishment and characterization of porcine cytolytic cell lines and clones. Vet Immunol Immunopathol. 1997 Nov;59(3-4):337-47.

Bouma A, Zwart RJ, De Bruin MG, De Jong MC, Kimman TG, Bianchi AT Immunohistological characterization of the local cellular response directed against pseudorabies virus in pigs. Vet Microbiol. 1997 Nov;58(2-4):145-54.

Van Nes, A., Stegeman, J.A., De Jong, M.C., Loeffen, W.L., Kimman, T.G., Verheijden, J.H., 1997, No massive spread of pseudorabies virus in vaccinated sow herds. Veterinary Microbiology 55, 147-151.

Peeters, B.P.H., K. Bienkowska-Szewczyk, M.M. Hulst, A.L.J. Gielkens and T. Kimman. (1997) Biologically safe, non-transmissible pseudorabies virus vector vaccine protects pigs against both Aujeszky’s disease and classical swine fever. J. Gen. Virol. 78: 3311-3315.

Jacobs L, Mulder W, Dercksen D, Vos J, Raymakers R, Kimman T Detection of wild-type Aujeszky's disease virus by polymerase chain reaction in sheep vaccinated with a modified live vaccine strain. Res Vet Sci. 1997 May-Jun;62(3):271-4.

Van Nes A, Stegeman JA, De Jong MC, Loeffen WL, Kimman TG, Verheijden JH. No massive spread of pseudorabies virus in vaccinated sow herds. Vet Microbiol. 1997 Apr;55(1-4):147-51.

Stegeman A, De Jong MC, Van der Heijden HM, Elbers AR, Kimman TG.Evaluation of tests for detection of antibodies to Aujeszky's disease (pseudorabies) virus glycoprotein E in the target population. Vet Microbiol. 1997 Apr;55(1-4):107-11.

Bouma A, De Jong MC, Kimman TG. The influence of maternal immunity on the transmission of pseudorabies virus and on the effectiveness of vaccination. Vaccine. 1997 Feb;15(3):287-94.

Bouma A, De Jong MC, Kimman TG.Comparison of two pseudorabies virus vaccines, that differ in capacity to reduce virus excretion after a challenge infection, in their capacity of reducing transmission of pseudorabies virus. Vet Microbiol. 1997 Feb;54(2):113-22.

Mulder, W.A.M., J.M.A. Pol, E. Gruys, L. Jacobs, M.C.M. de Jong, B.P.H. Peeters, T.G. Kimman. (1997) Pseudorabies virus infections in pigs. Role of viral proteins in virulence, pathogenesis and transmission. Vet. Res. 28: 1-17.

Stegeman, A., Elbers, A.R.W., Loeffen, W., De Jong, M.C.M., Tielen, M.J.M., 1996, Rate of successful pseudorabies virus introductions in swine breeding herds in the southern Netherlands that participated in an area-wide vaccination programme. Preventive Veterinary Medicine 27, 29-41.

Stegeman JA, de Jong MC, van der Heijden HM, Elbers AR, Kimman TG. Assessment of the quality of tests for the detection of antibodies to Aujeszky's disease virus glycoprotein gE in a target population by the use of receiver operating characteristic curves. Res Vet Sci. 1996 Nov;61(3):263-7.

Jacobs L, Kimman TG, Bianchi A. Lack of serum antibodies against glycoprotein E in pseudorabies virus-immune pigs infected with wild-type virus. Am J Vet Res. 1996 Nov;57(11):1525-8.

Van Nes A, Stegeman JA, De Jong MC, Loeffen WL, Kimman TG, Verheijden JH. No major outbreaks of pseudorabies virus in well-immunized sow herds. Vaccine. 1996 Aug;14(11):1042-4.

Kimman TG, DeBruin TG, Voermans JJ, Bianchi AT. Cell-mediated immunity to pseudorabies virus: cytolytic effector cells with characteristics of lymphokine-activated killer cells lyse virus-infected and glycoprotein gB- and gC-transfected L14 cells. J Gen Virol. 1996 May;77 ( Pt 5):987-90..

Mulder W, Pol J, Kimman T, Kok G, Priem J, Peeters B Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI. J Virol. 1996 Apr;70(4):2191-200.

Kimman TG, de Leeuw O, Kochan G, Szewczyk B, van Rooij E, Jacobs L, Kramps JA, Peeters B. An indirect double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) using baculovirus-expressed antigen for the detection of antibodies to glycoprotein E of pseudorabies virus and comparison of the method with blocking ELISAs. Clin Diagn Lab Immunol. 1996 Mar;3(2):167-74.

Hooft van Iddekinge BJ, de Wind N, Wensvoort G, Kimman TG, Gielkens AL, Moormann RJ. Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine fever in pigs; influence of different promoters on gene expression and on protection. Vaccine. 1996 Jan;14(1):6-12.

Bouma A, De Jong MC, Kimman TG  Transmission of two pseudorabies virus strains that differ in virulence and virus excretion in groups of vaccinated pigs. Am J Vet Res. 1996 Jan;57(1):43-7.

Glazenburg, K.L., B.P.H. Peeters, J.M.A. Pol, A.L.J. Gielkens, and R.J.M. Moormann. (1995) Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression. J. Virol. 69: 189-197.

Mulder WA, Priem J, Pol JM, Kimman TG. Role of viral proteins and concanavalin A in in vitro replication of pseudorabies virus in porcine peripheral blood mononuclear cells. J Gen Virol. 1995 Jun;76 ( Pt 6):1433-42.

Kimman TG, Bianchi AT, de Bruin TG, Mulder WA, Priem J, Voermans JJ. Interaction of pseudorabies virus with immortalized porcine B cells: influence on surface class I and II major histocompatibility complex and immunoglobulin M expression. Vet Immunol Immunopathol. 1995 Apr;45(3-4):253-63.

Kimman TG, Gielkens AL, Glazenburg K, Jacobs L, de Jong MC, Mulder WA, Peeters BP. Characterization of live pseudorabies virus vaccines. Dev Biol Stand. 1995;84:89-96. No abstract available.

Glazenburg KL, Moormann RJ, Kimman TG, Gielkens AL, Peeters BP. Genetic recombination of pseudorabies virus: evidence that homologous recombination between insert sequences is less frequent than between autologous sequences. Arch Virol. 1995;140(4):671-85.

Mulder WA, De Jong MC, Priem J, Bouma A, Pol JM, Kimman TG. Experimental quantification of transmission of genetically engineered pseudorabies virus. Vaccine. 1995 Dec;13(18):1763-9.

Kimman TG, De Bruin TM, Voermans JJ, Peeters BP, Bianchi AT. Development and antigen specificity of the lymphoproliferation responses of pigs to pseudorabies virus: dichotomy between secondary B- and T-cell responses. Immunology. 1995 Nov;86(3):372-8.

Wagenaar F, Pol JM, Peeters B, Gielkens AL, de Wind N, Kimman TG. The US3-encoded protein kinase from pseudorabies virus affects egress of virions from the nucleus. J Gen Virol. 1995 Jul;76 ( Pt 7):1851-9.

Peeters, B.P.H., T. Kimman, J. Pol, R. Moormann, and A. Gielkens. (1995) gD-negative herpes virus: a new generation of safe live vaccines and carrier vaccines. in: Vaccines 95, p305-310, Cold Spring harbor Laboratory Press, Cold Spring Harbor, NY, 1995.

Kimman TG, De Wind N, De Bruin T, de Visser Y, Voermans J. Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity. Virology. 1994 Dec;205(2):511-8.

Mulder WA, Jacobs L, Priem J, Kok GL, Wagenaar F, Kimman TG, Pol JM. Glycoprotein gE-negative pseudorabies virus has a reduced capability to infect second- and third-order neurons of the olfactory and trigeminal routes in the porcine central nervous system. J Gen Virol. 1994 Nov;75 ( Pt 11):3095-106.

Glazenburg KL, Moormann RJ, Kimman TG, Gielkens AL, Peeters BP. In vivo recombination of pseudorabies virus strains in mice. Virus Res. 1994 Nov;34(2):115-26.

Stegeman A, Van Oirschot JT, Kimman TG, Tielen MJ, Hunneman WA, Berndsen FW. Reduction of the prevalence of pseudorabies virus-infected breeding pigs by use of intensive regional vaccination. Am J Vet Res. 1994 Oct;55(10):1381-5.

Jacobs L, Kimman TG. Epitope-specific antibody response against glycoprotein E of pseudorabies virus. Clin Diagn Lab Immunol. 1994 Sep;1(5):500-5.

Glazenburg KL, Elgersma-Hooisma M, Briaire J, Voermans J, Kimman TG, Gielkens AL, Moormann RJ. Vaccine properties of pseudorabies virus strain 783 are not affected by a deletion of 71 base pairs in the promoter/enhancer region of the viral immediate early gene. Vaccine. 1994 Sep;12(12):1097-100.

De Wind N, Peeters BP, Zuderveld A, Gielkens AL, Berns AJ, Kimman TG. Mutagenesis and characterization of a 41-kilobase-pair region of the pseudorabies virus genome: transcription map, search for virulence genes, and comparison with homologs of herpes simplex virus type 1. Virology. 1994 May 1;200(2):784-90.

Stegeman JA, Tielen MJ, Kimman TG, Van Oirschot JT, Hunneman WA, Berndsen FW. Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections. Vaccine. 1994 May;12(6):527-31.

Stegeman JA, Kimman TG, Van Oirschot JT, Tielen MJ, Hunneman WA. Spread of Aujeszky's disease virus within pig herds in an intensively vaccinated region. Vet Rec. 1994 Mar 26;134(13):327-30

Peeters B, Bouma A, de Bruin T, Moormann R, Gielkens A, Kimman T. Non-transmissible pseudorabies virus gp50 mutants: a new generation of safe live vaccines. Vaccine. 1994 Mar;12(4):375-80.

Mulder WA, Priem J, Glazenburg KL, Wagenaar F, Gruys E, Gielkens AL, Pol JM, Kimman TG. Virulence and pathogenesis of non-virulent and virulent strains of pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus. J Gen Virol. 1994 Jan;75 ( Pt 1):117-24.

Jacobs L, Mulder WA, Priem J, Pol JM, Kimman TG. Glycoprotein I of pseudorabies virus (Aujeszky's disease virus) determines virulence and facilitates penetration of the virus into the central nervous system of pigs. Acta Vet Hung. 1994;42(2-3):289-300.

Jacobs L, Moonen-Leusen BM, Bianchi AT, Kimman TG. Glycoprotein gI of pseudorabies virus: epitope-specific antibody response in mice and pigs. Acta Vet Hung. 1994;42(2-3):347-51.

Bouwkamp FT, Stegeman JA, Kimman TG. Use of colostrum to detect antibodies against glycoprotein I of Aujeszky's disease virus. Vet Rec. 1993 Dec 11;133(24):591-3.

Jacobs L, Mulder WA, Van Oirschot JT, Gielkens AL, Kimman TG. Deleting two amino acids in glycoprotein gI of pseudorabies virus decreases virulence and neurotropism for pigs, but does not affect immunogenicity. J Gen Virol. 1993 Oct;74 ( Pt 10):2201-6.

Pensaert M, Gielkens AL, Lomniczi B, Kimman TG, Vannier P, Eloit M. Round table on control of Aujeszky's disease and vaccine development based on molecular biology. Vet Microbiol. 1992 Nov;33(1-4):53-67. Review.

Kimman TG, Pol JM, de Wind N, Oei-Lie N, Berns AJ, Gielkens AL.Role of different genes in the virulence and pathogenesis of Aujeszky's disease virus. Vet Microbiol. 1992 Nov;33(1-4):45-52..

Kimman TG, Oei-Lie N, van Zaane D. Role of memory B-cell responses in serum and mucosal fluids of swine for protective immunity against pseudorabies virus. Am J Vet Res. 1992 Nov;53(11):1992-8.

Kimman TG, Brouwers RA, Daus FJ, van Oirschot JT, van Zaane D. Measurement of isotype-specific antibody responses to Aujeszky's disease virus in sera and mucosal secretions of pigs. Vet Immunol Immunopathol. 1992 Feb 15;31(1-2):95-113.

Kimman TG, de Wind N, Oei-Lie N, Pol JM, Berns AJ, Gielkens AL. Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity. J Gen Virol. 1992 Feb;73 ( Pt 2):243-51.

Gielkens, A.L.J. and B.P.H. Peeters. (1994) Function of Aujeszky's disease virus proteins in virus replication and virulence. Acta Veterinaria Hungarica 42: 227-241.

Glazenburg, K.L., R.J.M. Moormann, T.G. Kimman, A.L.J. Gielkens, and B.P.H. Peeters. (1994) In vivo recombination of pseudorabies virus strains in mice. Virus Research 34: 115-126.

Peeters, B.P.H., J. Pol, A. Gielkens, and R. Moormann. (1993) Envelope glycoprotein gp50 of pseudorabies virus is essential for virus entry but is not required for viral spread in mice. J. Virol. 67: 170-177.

Peeters, B.P.H., N. de Wind, M. Hooisma, F. Wagenaar, A. Gielkens, and R. Moormann. (1992) Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion. J. Virol. 66: 894-905.

Peeters, B.P.H., N. de Wind, R. Broer, A. Gielkens, and R. Moormann. (1992) Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virus. J. Virol. 66: 3888-3892.

Kimman TG. Acceptability of Aujeszky's disease vaccines. Dev Biol Stand. 1992;79:129-36.

Kimman TG. Comparative efficacy of three doses of the genetically engineered Aujeszky's disease virus vaccine strain 783 in pigs with maternal antibodies. Vaccine. 1992;10(6):363-5.

van Oirschot JT, Daus F, Kimman TG, van Zaane D. Antibody response to glycoprotein I in maternally immune pigs exposed to a mildly virulent strain of pseudorabies virus. Am J Vet Res. 1991 Nov;52(11):1788-93.

Kimman TG, Binkhorst GJ, van den Ingh TS, Pol JM, Gielkens AL, Roelvink ME. Aujeszky's disease in horses fulfils Koch's postulates. Vet Rec. 1991 Feb 2;128(5):103-6.

van den Ingh TS, Binkhorst GJ, Kimman TG, Vreeswijk J, Pol JM, van Oirschot JT. Aujeszky's disease in a horse. Zentralbl Veterinarmed B. 1990 Sep;37(7):532-8.

Kimman TG, van Oirschot JT. Pathology of Aujeszky's disease in mink. Vet Pathol. 1986 May;23(3):303-9.