Publicaties/publications Lama single-domain antilichaam fragmenten/Llama single-domain antibody fragments

Harmsen, M.M.; Blokker, J.C.; Pritz-Verschuren, S.B.; Bartelink, W.; Van der Burg, H.; Koch, G. 2013. Isolation of panels of llama single-domain antibody fragments binding all nine neuraminidase subtypes of influenza A virus. Antibodies 2, 168-192.

Trilling, A.K.; Harmsen, M.M.; Ruigrok, V.J.; Zuilhof, H.; Beekwilder, J. 2013. The effect of uniform capture molecule orientation on biosensor sensitivity: Dependence on analyte properties. Biosens. Bioelectron. 40, 219-226.

Seago, J.; Jackson, T.; Doel, C.; Fry, E.; Stuart, D.; Harmsen, M.M.; Charleston, B.; Juleff, N. 2012. Characterization of epitope-tagged foot-and-mouth disease virus. J. Gen. Virol. 93, 2371-2381.

Harmsen, M.M.; Fijten, H.P.D. 2012. Improved functional immobilization of llama single-domain antibody fragments to polystyrene surfaces using small peptides. J. Immunoassay Immunochem. 33, 234-251.

Harmsen M.M., Fijten H.P., Westra D.F., Coco-Martin J.M. 2011. Effect of thiomersal on dissociation of intact (146S) foot-and-mouth disease virions into 12S particles as assessed by novel ELISAs specific for either 146S or 12S particles. Vaccine 29, 2682-2690.

Harmsen, M.M., Jansen, J., Westra, D.F., Coco-Martin, J.M. 2010. Characterization of foot-and-mouth disease virus antigen by surface-enhanced laser desorption ionization-time of flight-mass spectrometry in aqueous and oil-emulsion formulations. Vaccine 28, 3363-3370.

Harmsen, M.M., Van Solt, C.B., Fijten, H.P.D. 2009. Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation. Appl. Microbiol. Biotechnol. 84,1087-1094.

Harmsen, M.M. Fijten, H.P.D., Engel, B., Dekker, A., Eblé, P.L. 2009. Passive immunization with llama single-domain antibody fragments reduces foot-and-mouth disease transmission between pigs. Vaccine 27, 1904-1911.

Harmsen, M.M. Fijten, H.P.D., Dekker, A., Eblé, P.L. 2008. Passive immunization of pigs with bispecific llama single-domain antibody fragments against foot-and-mouth disease and porcine immunoglobulin. Vet. Microbiol. 132, 56-64.

Harmsen, M.M., De Haard, H.J. 2007. Properties, production and applications of camelid single-domain antibody fragments. Appl. Microbiol. Biotechnol. 77, 13-22.

Harmsen, M.M., Van Solt, C.B., Fijten, H.P.D., Van Keulen, L., Rosalia, R.A., Weerdmeester, K., Cornelissen, A.H.M., De Bruin, M.G.M., Eblé, P.L., Dekker, A. 2007. Passive immunization of guinea-pigs with llama single-domain antibody fragments against foot-and-mouth disease. Vet. Microbiol. 120, 193-206.

Harrison, R.A., Hasson, S.S., Harmsen, M., Laing, G.D., Conrath, K., Theakston, R.D. 2006. Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera. Toxicon 47, 364-368.

Harmsen, M.M., van Solt, C.B., van Zijderveld-van Bemmel, A.M., Niewold, T.A., van Zijderveld, F.G. 2006. Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy. Appl. Microbiol. Biotechnol. 72, 544-551.

Harmsen, M.M., Van Solt, C.B., Fijten, H.P.D., Van Keulen, L., Rosalia, R.A., Weerdmeester, K., Cornelissen, A.H.M., De Bruin, M.G.M., Eblé, P.L., Dekker, A. 2006. Foot-and-mouth disease immunoprophylaxis using single-domain antibody fragments. FAO publication, 1-6.

Harmsen, M.M., Jansen, J., Westra, D., Coco-Martin, J.M. 2006. A novel proteomics-based approach for the characterization of FMDV antigens. FAO publication, 1-3. 

Borgsteede, F.H., Timmerman, A., Harmsen, M.M. 2006. A case of very serious Sarcoptes mange in alpacas (Lama pacos). Tijdschr. Diergeneeskd. 131, 282-283.

Harmsen, M.M., van Solt, C.B., Hoogendoorn, A., van Zijderveld, F.G., Niewold, T.A., van der Meulen, J. 2005. Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea. Vet. Microbiol. 111, 89-98.

Harmsen, M.M., Van Solt, C.B., Fijten, H.P.D., Van Setten, M.C. 2005. Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins. Vaccine 23, 4926-4934.

Harmsen, M.M., Smits, C.B., De Geus, B. 2002. Stimulation of chymosin secretion by simultaneous expression with chymosin-binding llama single-domain antibody fragments in yeast. Appl. Microbiol. Biotechnol. 60, 449-454.

Harmsen, M.M., Ruuls, R.C., Nijman, I.J., Niewold, T.A., Frenken, L.G.J., De Geus, B. 2000. Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features. Mol. Immunol. 37, 579-590.

Van der Linden, R.H.; De Geus, B.; Frenken, G.J.; Peters, H.; Verrips, C.T. 2000. Improved production and function of llama heavy chain antibody fragments by molecular evolution. J. Biotechnol. 80, 261-270.

Frenken, L.G.J.; van der Linden, R.H.; Hermans, P.W.; Bos, J.W.; Ruuls, R.C.; de Geus, B.; Verrips, C.T. 2000. Isolation of antigen specific llama VHH antibody fragments and their high level secretion by saccharomyces cerevisiae. J. Biotechnol. 78, 11-21.

Van der Linden, R.H.J., Frenken, L.G.J., de Geus, B., Harmsen, M.M., Ruuls, R.C., Stok, W., de Ron, L., Wilson, S., Davis, P., Verrips, C.T. 1999. Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies. Biochim. Biophys. Acta 1431, 37-46.