Publicaties/publications Scrapie

Hagenaars, T. J., Windig, J. J. 2015. Investigation of a Simple Model for Within-Flock Transmission of Scrapie. PLoS ONE 10 (10): e0139436.

Hagenaars, T. J. 2014. Control of scrapie by selective breeding: what are we getting for free? Vet. Rec. 174: 528-529 (editorial)

Bannach, O.; Birkmann, E.; Reinartz, E.; Karl-Erich, J.; Langeveld, J.P.M.; Rohwer, R.G.; Gregori, L.; Terry, L.A.; Willbold, D.; Riesner, D. (2012); Detection of Prion Protein Particles in Blood Plasma of Scrapie Infected Sheep; PLoS One 7 (5). - p. 8.Octrooinummer: e36620.

Tang, Y.; gielbert, A.; Jacobs, J.G.; Baron, T.; Andreoletti, O.; Langeveld, J.P.M.; Sauer, M.J. (2012); All major prion types recognised by a multiplex immunofluorometric assay for disease screening and confirmation in sheep; Journal of Immunological Methods 380 (1-2). - p. 30 - 39.

Bouzalas, I.; Lörtscher, F.; Dovas, C.; Oevermann, A.; Langeveld, J.P.M.; Papanastassopoulou, M.; Papadopoulos, O.; Zurbriggen, A.; Seuberlich, T. (2011); A distinct proteinase K resistant prion protein fragment in goats with no signs of disease in a classical scrapie outbreak; Journal of Clinical Microbiology 49 (6). - p. 2109 - 2115.

Filali, H.; Martin-Burriel, I.; Harders, F.; Varona, L.; Lyahyai, J.; Zaragoza, P.; Pumarola, M.; Badiola, J.J.; Bossers, A.; Bolea, R. (2011); Gene expression profiling en association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals; PLoS One 6 (5). - p. 12.Octrooinummer: e19909.

Goldmann, W.; Ryan, K.; Stewart, P.; Parnham, D.; Xicohtencatl, R.; Fernandez, N.; Saunders, G.; Windl, O.; Gonzalez, L.; Bossers, A. (2011); Caprine prion genen polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom; Veterinary Research 42 . - p. 8pp.

Jacobs, J.G.; Sauer, M.; Keulen, L.J.M. van; Tang, Y.; Bossers, A.; Langeveld, J.P.M. (2011); Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie; Journal of General Virology 92 (1). - p. 222 - 232.

Jacobs, J.G.; Bossers, A.; Rezaei, H.; Van Keulen, L.; McCutcheon, S.; Sklaviadis, T.; Lantier, I.; Berthon, P.; Lantier, F.; Zijderveld, F.G. van; Langeveld, J.P.M. (2011); Proteinase K resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein; Journal of Virology 85 . - p. 12537 - 12546.

Melchior, M.B.; Hagenaars, T.J.; Davidse, A.; Keulen, L. van; Bossers, A.; Zijderveld, F.G. van (2011); Active surveillance for scrapie in the Netherlands: effect of a breeding programme on the prevalence of scrapie in sheep (2002-2010); Tijdschrift voor Diergeneeskunde 136 (2). - p. 84 - 93.

Nodelijk, G.; Roermund, H.J.W. van; Keulen, L.J.M. van; Engel, B.; Vellema, P. (2011); Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks; Veterinary Research 42 (1). - p. 5.

Rigter, A.; Priem, J.; Langeveld, J.P.M.; Bossers, A. (2011); Prion protein self-interaction in prion disease therapy approaches; Veterinary Quarterly 31 (3). - p. 115 - 128.

González, L.; Sisó, S.; Monleón, E.; Casalone, C.; Keulen, L.J.M. van; Balkema-Buschmann, A.; Ortiz-Peláez, A.; Lulini, B.; Langeveld, J.P.M.; Hoffmann, C.; Badiola, J.J.; Jeffrey, M.; Acín, C. (2010); Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe; Journal of General Virology 91 . - p. 2630 - 2641.

Gubbins, S.; Touzeau, S.; Hagenaars, T.J. (2010); The role of mathematical modelling in understanding the epidemiology and control of sheep transmissible spongiform encephalopathies: a review; Veterinary Research 41 (4). - p. 41:42.

Hagenaars, T.J.; Melchior, M.B.; Bossers, A.; Davidse, A.; Engel, B.; Zijderveld, F.G. van (2010); Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance; BMC Veterinary Research 6 . - p. 25.

Melchior, M.B.; Windig, J.J.; Hagenaars, T.J.; Bossers, A.; Davidse, A.; Zijderveld, F.G. van (2010); Eradication of scrapie with selective breeding: are we nearly there?; BMC Veterinary Research 6 . - p. 24.

Pirisinu, L.; Di Bari, M.; Marcon, S.; Vaccari, G.; D'Agostino, C.; Fazzi, P.; Esposito, E.; Cardone, F.; Langeveld, J.P.M.; Agrimi, U.; Nonno, R. (2010); A new method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease Resistant PrPSc; PLoS One 5 . - p. 12723.

Polak,M.P.; Larska, M.; Langeveld, J.P.M.; Buschmann, A.; Groschup, M.H.; Zmudzinski,J.F. (2010); Diagnosis of the first cases of scrapie in Poland; The VeterinaryJournal 186 (1). - p. 47 - 52.

Rigter, A.;Langeveld, J.P.M.; Zijderveld, F.G. van; Bossers, A. (2010); Prion Protein SelfInteractions; a gateway to novel therapeutic strategies?; Vaccine 28 (49). - p.7810 - 7823.

Tang, Y.;Thorne, J.; Whatling, K.L.; Jacobs, J.G.; Langeveld, J.P.M.; Sauer, M. (2010);Asingle step multiplex immunofluorometric assay for differential diagnosis ofBSE and scrapie; Journal of Immunological Methods 356 (1-2). - p. 29 - 38.

Windig,J.J.; Hoving-Bolink, A.H.; Hiemstra, S.J. (2010); Selection for scrapie resistancedecreased inbreeding rates in two rare sheep breeds in the Netherlands; In:Proceedings of the 9th World Congress on Genetic Applied to LivestockProduction (WCGALP), Leipzig, Germany, 1-6 August 2010. -

Cali, I.;Castellani, R.; Alshekhlee, A.; Cohen, Y.; Blevins, J.; Yuan, J.; Langeveld,J.P.M.; Parchi, P.; Safar, J.G.; Zou, W.Q.; Gambetti, P. (2009); Co-existence of scrapie prion protein types 1 and 2 insporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-typecharacteristics; Brain 132 . - p. 2643 - 2658.

Orrú, C.D.;Wilham, J.M.; Hughson, A.G.; Raymond, L.D.; McNally, K.L.; Bossers, A.; Ligios,C.; Caughey, B. (2009); Human VariantCreutzfeldt-Jakob disease and sheep scrapie PrP (res) detection using seededconversion of recombinant prion protein.; Protein Engineering, Design& Selection 22 (8). - p. 515 - 521.

Rigter, A.;Priem, J.; Timmers-Parohi, D.; Langeveld, J.P.M.; Zijderveld, F.G. van;Bossers, A. (2009); Prion protein self-peptides modulate prion interactions andconversion; BMC Biochemistry 10 . - p. 29.

Vaccari,G.; Panagiotidis, C.H.; Acin, C.; Peletto, S.; Barillet, F.; Acutis, P.;Bossers, A.; Langeveld, J.P.M.; Keulen, L.J.M. van; Sklaviadis, T.; Badiola,J.J.; Andreoletti, O.; Groschup, M.H.; Agrimi, U.; Foster, J.; Goldmann, W.(2009); State-of-the-art review of goat TSE in the European Union, with specialemphasis on PRNP genetics and epidemiology; Veterinary Research 40 (5). - p.48.

Acutis,P.L.; Colussi, S.; Santagada, G.; Laurenza, C.; Maniaci, M.G.; Riina, M.V.;Peletto, S.; Goldmann, W.; Bossers, A.; Caramelli, M.; Cristoferi, I.; Maione,S.; Sacchi, P.; Rasero, R. (2008); Genetic variability of the PRNP gene in goatbreeds from Northern and Southern Italy; Journal of Applied Microbiology 104(6). - p. 1782 - 1789.

Keulen,L.J.M. van; Bossers, A.; Zijderveld, F.G. van (2008); TSE pathogenesis incattle and sheep; Veterinary Research 39 (4). - p. 24.

Keulen,L.J.M. van; Vromans, M.E.W.; Dolstra, C.H.; Bossers, A.; Zijderveld, F.G. van(2008); Pathogenesis of bovine spongiform encephalopathy in sheep; Archives ofVirology 153 (3). - p. 445 - 453.

Espinosa,J.C.; Andreoletti, O.; Castilla, J.; Herva, M.E.; Morales, M.; Alamillo, E.;San-Segundo, F.D.; Lacroux, C.; Lugan, S.; Salguero, F.J.; Langeveld, J.P.M.;Torres, J.M. (2007); Sheep-passaged bovine spongiform encephalopathy agentexhibits altered pathobiological properties in bovine-PrP transgenic mice;Journal of Virology 81 (2). - p. 835 - 843.

Rigter, A.;Langeveld, J.P.M.; Timmers-Parohi, D.; Jacobs, J.G.; Moonen, P.L.J.M.; Bossers,A. (2007); Mapping of possible prion protein self interaction domains usingpeptide arrays; Biochemistry 8 . - p. 6.

Acutis,P.L.; Bossers, A.; Priem, J.; Riina, M.V.; Peletto, S.; Mazza, M.; Casalone,C.; Forloni, G.; Ru, G.; Caramelli, M. (2006); Identification of prion proteingene polymorphisms in goats from Italian scrapie outbreaks; Journal of GeneralVirology 87 . - p. 1029 - 1033.

Gretzschel,A.; Buschmann, A.; Langeveld, J.P.M.; Groschup, M.H. (2006); Immunological characterization of abnormal prionprotein from atypical scrapie cases in sheep using a panel of monoclonalantibodies; Journal of General Virology 87 . - p. 3715 - 3722.

Hagenaars,T.J.; Donnelly, C.; Ferguson, N.M. (2006) Epidemiological analysis of data forscrapie in Great Britain, Epidemiology and Infection 134 (2). - p. 359 - 367.

Jeffrey,M.; Martin, S.; Gonzalez, L.; Foster, J.; Langeveld, J.P.M.; Zijderveld, F.G.van; Grassi, J.; Hunter, N. (2006); Immunohistochemical features of Prp(d)accumulation in natural and experimental goat transmissible spongiformencephalopathies; Journal of Comparative Pathology 134 (2-3). - p. 171 - 181.

Langeveld,J.P.M.; Jacobs, J.G.; Erkens, J.H.F.; Bossers, A.; Zijderveld, F.G. van;Keulen, L.J.M. van (2006); Rapid and discriminatory diagnosis of scrapie andBSE in retro-pharyngeal lymph nodes of sheep; BMC Veterinary Research 2 . - p.19.

Raymond,G.J.; Olsen, E.A.; Lee, K.S.; Raymond, L.D.; Bryant, P.K.; Baron, G.S.;Caughey, W.S.; Kocisko, D.A.; McHolland, L.E.; Favara, C.; Langeveld, J.P.M.;Zijderveld, F.G. van; Mayer, R.T.; Miller, M.W.; Williams, E.S.; Caughey, B.(2006); Inhibition of protease-resistant prion protein formation in atransformed deer cell line infected with chronic wasting disease; Journal ofVirology 80 (2). - p. 596 - 604.

Rigter, A.;Bossers, A. (2005); Sheep scrapiesusceptibility-linked polymorphisms do not modulate the initial binding ofcellular to disease-associated prion protein prior to conversion;Journal of General Virology 86 (9). - p. 2627 - 2634.

Sharpe, A.;McElroy, M.; Langeveld, J.P.M.; Bassett, H.; O'Donoghue, A.M.; Sweeney, T.(2005); Immunohistochemical studies of scrapiearchival material from Irish ARQ/ARQ sheep for evidence of bovine spongiformencephalopathy-derived disease; Research in Veterinary Science 79(1). - p. 29 - 35.

Thuring,C.M.A.; Keulen, L.J.M. van; Langeveld, J.P.M.; Vromans, M.E.W.; Zijderveld,F.G. van; Sweeney, T. (2005); Immunohistochemical distinction betweenpreclinical bovine spongiform encephalopathy and scrapie infection in sheep;Journal of Comparative Pathology 132 (1). - p. 59- - 69.

Veerhuis,R.; Boshuizen, R.S.; Morbin, M.; Mazzoleni, G.; Hoozemans, J.J.; Langedijk,J.P.; Tagliavini, F.; Langeveld, J.P.M.; Eikelenboom, P. (2005); Activation ofhuman microglia by fibrillar prion protein-related peptides is enhanced byamyloid-associated factors SAP and C1q; Neurobiology of Disease 19 (1-2). - p.273 - 282.

Acutis,P.L.; Sbaiz, L.; Verburg, F.J.; Riina, M.V.; Ru, G.; Moda, G.; Caramelli, M.;Bossers, A. (2004); Low frequency of the scrapileresistance-associated allele and presence of lysine-171 allele of the prionprotein gene in Italian Biellese ovine breed; Journal of GeneralVirology 85 . - p. 3165 - 3172.

Bate, C.;Langeveld, J.P.M.; Williams, A. (2004); Manipulation of PrPres production inscrapie-infected neuroblastoma cells; Journal of Neuroscience Methods 138(1-2). - p. 217 - 223.

Thuring,C.M.A.; Erkens, J.H.F.; Jacobs, J.G.; Bossers, A.; Keulen, L.J.M. van; Garssen,G.J.; Zijderveld, F.G. van; Ryder, S.J.; Groschup, M.H.; Sweeney, T.;Langeveld, J.P.M. (2004); Discrimination betweenscrapie and bovine spongiform encephalopathy in sheep by molecular size,immunoreactivity, and glycoprofile of prion protein; Journal ofClinical Microbiology 42 (3). - p. 972 - 980.

Hagenaars,T.J.; Donelly, C.A.; Ferguson, N.M.; Anderson, R.M. (2003); Dynamics of ascrapie outbreak in a flock of Romanov sheep-estimation of transmissionparameters; Epidemiology and Infection 131 . - p. 1015 - 1022.

Langeveld,J.P.M.; Wang, J.J.; Wiel, D.F.M. van de; Shih, G.C.; Garssen, G.J.; Bossers,A.; Shih, J.C.H. (2003); Enzymatic degradation of prion protein in brain stemfrom infected cattle and sheep; The Jounal of Infectious Diseases 188 (11). -p. 1782 - 1789.

Bate, C.;Boshuizen, R.S.; Langeveld, J.P.M.; Williams, A. (2002); Temporal and spatialrelationship between the death of PrP-damaged neurones and microglialactivation; NeuroReport 13 (13). - p. 1695 - 1700.

Keulen,L.J.M. van; Vromans, M.E.W.; Zijderveld, F.G. van (2002); Early and latepathogenesis of natural scrapie infection in sheep; Apmis 110 (1). - p. 23 -32.

Sigurdson,C.J.; Barillas-Mury, C.; Miller, M.W.; Oesch, B.; Keulen, L.J.M. van;Langeveld, J.P.M.; Hoover, E.A. (2002); PrPCWD lymphoid cell targets in earlyand advanced chronic wasting disease of mule deer; Journal of General Virology83 (10). - p. 2617 - 2628.

Andreoletti,O.; Berthon, P.; Marc, D.; Sarradin, P.; Grosclaude, J.; Keulen, L. van;Schelcher, F.; Elsen, J.M.; Lantier, F. (2000); Early accumulation of PrPSc in gut-associated lymphoidand nervous tissues of susceptible sheep from a Romanov flock with naturalscrapie; Journal of general virology 81 Part 12, 3115-3126

Garssen,G.J.; Keulen, L.J.M. van; Farquhar, C.F.; Smits, M.A.; Jacobs, J.G.; Bossers,A.; Meloen, R.H.; Langeveld, J.P.M. (2000); Applicability of three anti-PrPpeptide sera including staining of tonsils and brainstem of sheep with scrapie;Microscopy research and technique 50, 2000, 32-39

Keulen,L.J. van; Schreuder, B.E.; Vromans, M.E.; Langeveld, J.P.; Smits, M.A. (2000);Pathogenesis of natural scrapie in sheep; Archives of Virology, Supplement,57-71

Bossers, A.(1999); Prion diseases: Susceptibility and transmissibility. In vivo and invitro studies with sheep scrapie; Thesis, 1999. - ISBN 90-393-2108-6

Bossers,A.; Harders, F.L.; Smits, M.A. (1999); PrP genotype frequencies of the mostdominant sheep breed in a country free from scrapie; Archives of virology 144,1999, 829-834

Keulen,L.J.M. van; Schreuder, B.E.C.; Vromans, M.E.W.; Langeveld, J.P.M.; Smits, M.A.(1999); Scrapie-associated prion protein in the gastro-intestinal tract ofsheep with natural scrapie; Journal comparative pathology 121, 1999, 55-63

Roels, S.;Vanopdenbosch, E.; Langeveld, J.P.M.; Schreuder, B.E.C. (1999);Immunohistochemical evaluation of tonsillar tissue for preclinical screening ofscrapie based on surveillance in Belgium; Veterinary Record 145 (18). - p. 524- 525.

Schreuder,B.E.C.; Geertsma, R.E.; Keulen, L.J.M. van; Asten, J.A.A.M. van; Enthoven, P.;Oberthür, R.C.; Koeijer, A.A. de; Osterhaus, A.D.M.E. (1998); Studies on the efficacy of hyperbaric renderingprocedures in inactivating bovine spongiform encephalopathy (BSE) and scrapieagents; Veterinary Record 142 (19). - p. 474 - 480.

Schreuder,B.E.C.; Keulen, L.J.M. van; Vromans, M.E.W.; Langeveld, J.P.M.; Smits, M.A.(1998); Tonsillar biopsy and PrPSc detection in the preclinical diagnosis ofscrapie; Veterinary Record 142 (21). - p. 564 - 568.

Raymond,G.J.; Hope, J.; Kocisko, D.A.; Priola, S.A.; Raymond, L.D.; Bossers, A.;Ironside, J.; Will, R.G.; Chen, S.G.; Petersen, R.B.; Gambetti, P.; Rubenstei,R.; Smits, M.A.; Lansbury, P.T.; Caughey, B. (1997); Molecular assessment ofthe potential transmissibilities of BSE and scrapie to humans; Nature 388,1997, 285-288

Smits,M.A.; Bossers, A.; Schreuder, B.E.C. (1997); Prion protein and scrapiesusceptibility; Veterinary quarterly 19, 1997, 101-105

Keulen,L.J.M. van; Schreuder, B.E.C.; Meloen, R.H.; Mooij-Harkes, G.; Vromans, M.E.W.;Langeveld, J.P.M. (1996); Immunohistochemical detection of prion protein inlymphoid tissues of sheep with natural scrapie; Journal clinical microbiology34, 1996, 1228-1231

Belt,P.B.G.M.; Muileman, I.H.; Schreuder, B.E.C.; Bos-de Ruijter, J.; Gielkens,A.L.J.; Smits, M.A. (1995); Identification of five allelic variants of thesheep PrP gene and their association with natural scrapie; Journal of generalvirology 76, 1995, 509-517

Keulen,L.J.M.; Schreuder, B.E.C.; Meloen, R.H.; Poelen-van der Berg, M.; Mooij-Harkes,G.; Vromans, M.E.W.; Langeveld, J.P.M. (1995); lmmunohistochemical detectionand localization of prion protein in brain tissue of sheep with naturalscrapie; Veterinary pathology 32, 1995, 299-308