Project

ESBL’s en interventie (in English)

Extended Spectrum Beta-lactamase producing (ESBL) and AmpC Beta-lactamase (AmpC) producing bacteria are found in increasing numbers in humans and animals since the year 2000. Recent research by the UMCU, CVI, the RIVM and VUMC has shown that there is a clear genetic relation between the ESBL and AmpC producing bacteria that cause clinical infections in humans and the bacteria that are found in poultry and poultry meat.


ESBL's and interventions

To reduce the risk of human infections by farm animals it is important to reduce the number of ESBL and/or AmpC producering bacteria in farm animals. To achieve this more knowlegde is needed about interventions that can be used to reduce the number of ESBL and/or AmpC producering bacteria in farm animals.

For 2013 the objectives are:

  • To make a list of intervention strategies in poultry based on literature and epxerts
  • Developing a model in chickens and testing intervention measures in an animal transmission model
  • A cost analysis of the intevention measures, this will be continued in 2014

The intended results are:

  • An inventarisation of possible interventies to reduce the number of ESBL and/or AmpC producing bacteria at poultry farms.
  • An animal model to measure the effect of interventions on the reduction of the number of ESBL and/or AmpC producing bactera. Thess animal models can be used in the future to test new intervention strategies in poultry.
  • Kwantitative data about the effect of interventionstrategies on the reduction of the spread and numbers of ESBL en/of AmpC producing bacteria in an experimental setting at flock level in poultry.
  • A cost analysis of intervention measures at farm level of poultry farms, this will be finished in 2014.

Publications


Extended Spectrum Beta-lactamase producing (ESBL) and AmpC Beta-lactamase (AmpC) producing bacteria are found in increasing numbers in humans and animals since 2000. To reduce the risk of human infections from the animal reservoir, knowledge has to be generated to decrease the number of Extended Spectrum Beta-lactamase producing (ESBL) and AmpC Beta-lactamase (AmpC) producing bacteria in farm animals.

The aims of this project are the inventarisation and experimental testing of interventions to decrease or prevent the transmission of ESBL and AmpC producing bacteria between animals. The effect of the interventions is initially tested in an experimental setting, and subsequently in a field trial. In addition a cost analysis of the interventions is performed.

The project has started with an experimental model for broilers, the most successful interventions will be tested in a field trial at broiler farms. The second part of the project will focus on calves or pigs.

It is expected that the project will return several interventions that are applicable at farm level and that will decrease the number of Extended Spectrum Beta-lactamase producing (ESBL) and AmpC Beta-lactamase (AmpC) producing bacteria at the farms.


Publications