The twenty-first century is facing the challenge of an accelerating speed of ageing, and with it an increasing prevalence of ageing-related pathologies. Specific age-related conditions, which predominantly affect older people, include dementia (cognitive decline), depression, prediabetes and diabetes, which all rise sharply with age.
A number of epidemiological human studies suggest there are important links between these pathologies, and that they may even share common nutritional risk factors. One of these, a seemingly novel and very relevant risk factor, is Vitamin D. These findings are important, as it is widely recognized that vitamin D status is suboptimal in older adults. The project 4xD (Vitamin D for preventing Dementia and Depression in Diabetes) focusses on the links between prediabetes and diabetes, dementia and depression on the one hand and vitamin D as a joint and novel predisposing factor for these conditions on the other.
Cognitive performance: a cross-sectional study on serum vitamin D and its interplay with glucose homeostasis in Dutch older adults
Journal of the American Medical Directors Association 16 (2015)7. - ISSN 1525-8610 - p. 621 - 627.
Vitamin D and cognition in older adults: an update of recent findings
Current Opinion in Clinical Nutrition and Metabolic Care 18 (2015)1. - ISSN 1363-1950 - p. 11 - 16.
No role for vitamin D or a moderate fat diet in aging induced cognitive decline and emotional reactivity in C57BL/6 mice
Behavioural Brain Research 267 (2014). - ISSN 0166-4328 - p. 133 - 143.
Marketing the use of 25-hydroxyvitamin D3 to enhance cognition
Octrooinummer: US 20140296190 A1, verleend: 2014-10-02.
Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression
Journal of the American Medical Directors Association 14 (2013)1. - ISSN 1525-8610 - p. 852.e9 - 852.e17.
Vitamin D. Do we get enough?
Osteoporis International 24 (2013)5. - ISSN 0937-941X - p. 1567 - 1577.
Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study
European Journal of Nutrition 52 (2013)3. - ISSN 1436-6207 - p. 917 - 925.
Vitamin D and the association with cognitive performance, cognitive decline, and dementia
In: Diet and Nutrition in Dementia and Cognitive Decline / , Martin, C.R., Preedy, V.R.. - Oxford : Elsevier - ISBN 9780124078246 - p. 679 - 700.
More research: Nutrition and ageing