B-vitamins in the prevention of osteoporotic fractures in elderly people

Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Observational evidence suggests that an elevated homocysteine concentration and poor vitamin B12 and folate status are associated with an increased fracture risk.

As vitamin B12 and folate intake and status play a large role in homocysteine metabolism, B-PROOF examines whether supplementation with these B-vitamins will reduce fracture incidence in elderly people with an elevated homocysteine concentration. Furthermore beneficial effects on neurological, cardiovascular, functional performance and metabolic outcomes are tested.


More research: Nutrition and ageing