Prebiotics to combat the side effects of antibiotics

Despite curing infectious diseases, antibiotic treatments also impact untargeted bacteria from the intestinal microflora, which may result in intestinal disorders. Prebiotics are dietary fibres that stimulate the beneficial bacteria from the intestinal microflora. Prebiotics may, therefore, reduce the side effects of antibiotics on the microflora. In this thesis, we investigated whether and how galacto-oligosaccharides (GOS), a known prebiotic, could counter the side effects of frequently used antibiotics in Europe.

Promovendus SE (Stephanie) Ladirat MSc
Promotor H (Harry) Gruppen
prof.dr. HA (Henk) Schols
Organisatie Wageningen University, Laboratory of Food Chemistry

vr 28 februari 2014 11:00 tot 12:30

Locatie Auditorium, building number 362
Generaal Foulkesweg 1
6703 BG Wageningen
Galacto-oligosaccharides are relevant in the recovery of the human microbiota after specific antibiotic treatment.
Stéphanie Émilie Ladirat

In vitro screening experiments revealed that the recovery of the intestinal microflora upon the addition of GOS was antibiotic dependant. A successful recovery was observed for a treatment with Amoxicillin, an antibiotic frequently inducing diarrhoea. GOS directly stimulated the beneficial bifidobacteria and indirectly stimulated the activity of other groups of bacteria. These positive effects were also seen in a small human trial with healthy volunteers. Our results may offer new opportunities for e.g. medical nutrition.