On January 16th the Wageningen Centre for Systems Biology (WCSB) will organise a seminar on systems biology. The seminar is free, will take an hour and will be followed by drinks. No registration is necessary, so feel free to come by!
Matthias Reuss, Centre systems Biology, University of Stuttgart
"Multiscale modeling for linking subcellular networks with cellular behavior at tissue level"
Simulations of biological phenomena linked to strongly interrelated and interacting phenomena at different scales in space and time is being recognized as a very important issue and generally denoted as multi scale modeling. A growing number of examples already illustrate the value of approaches developed for the solution of these problems. The difficult problem is not only to model the system at the different scales but in particular to deal with the mutual coupling between the scales. Thus, it is the bridging between the different levels within the overall system or the management of the relationships across multiple scales, which is the most challenging task to be solved in this field. Please notice that this is not only a mathematical and computational problem: There are many different research communities specialized at modeling the phenomena at different scales and as such management of the relationship across multiple scales also requires an integration of these groups in the sense of interdisciplinary networking.
The lecture aims at discussing some of the approaches in the field of multiscale modeling in cancer research to improve computer aided prediction of therapies. Emphasis is given to agent based modeling linked to state variables modeled as continuum at the tissue level and subcellular models taking care of key events in the cell cycle as well as dynamic models of intracellular signal transduction to simulate the action of selected drugs. The approach allows to distinguish the individual behavior of different cell types but also to simulate properties of the system emerging from the interaction of their parts. In the conclusion of the lecture special emphasis is given to the transfer of the methodologies to other important biological problems.
More information about WCSB and the 14 different projects can be found on the website www.wur.nl/systemsbiology.