In this study, we analyzed 22 strawberry and soil samples after their collection over the course of 2 years to compare the residue profiles from organic farming to integrated pest management practices in Portugal. For sample preparation, we used the citrate-buffered version of the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. We applied three different methods for analysis: (i) 27 pesticides were targeted using LC-MS/MS; (ii) 143 were targeted using low pressure GC - tandem mass spectrometry (LP-GC-MS/MS); and (iii) More than > 600 pesticides were screened in a targeted and untargeted approach using comprehensive, two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOF-MS). Comparison was made of the analyses using the different methods for the shared samples. The results were similar, thereby providing satisfactory confirmation of both similarly positive and negative findings. No pesticides were found in the organic-farmed samples. In samples from integrated pest management practices, 9 pesticides were determined and confirmed to be present ranging from 2 µg kg-1 for fluazifop-p-butyl to 50 µg kg-1 for fenpropathrin. Concentrations of residues in strawberries were less than European maximum residue limits.