Energie status en de ontwikkeling van follikels in het ovarium

Promotie

Energie status en de ontwikkeling van follikels in het ovarium

Promovendus Meng Li
Promotor Jaap prof.dr.ir. J (Jaap) Keijer
Copromotor Katja dr. KJ (Katja) Teerds
Organisatie Wageningen University, Leerstoelgroep Fysiologie van mens en dier
Datum

wo 7 december 2016 13:30 tot 15:00

Locatie Aula, gebouwnummer 362
Generaal Foulkesweg 1
362
6703 BG Wageningen
0317-483592

Samenvatting

As female reproduction is tightly linked to body energy status, it is not surprising that disturbed energy metabolism may negatively influence reproductive performance. The overall goal of this thesis was therefore to investigate the effects of an altered energy status on ovarian follicular development in more detail, using two animal models with altered energy status; a diet-induced thyroid hormone deficiency model affecting whole body metabolism, and a genetic model of lower availability of metabolic fuels (glucose, fatty acids and amino acids). The results of this thesis provide new insights in the mechanisms of ovarian follicle degeneration and show that conditions that alter metabolic fuel distribution, influence ovarian follicular development and thus female fertility.