Energy status and ovarian follicular development


Energy status and ovarian follicular development

Promovendus Meng Li
Promotor J (Jaap) Keijer
Copromotor dr. KJ (Katja) Teerds
Organisatie Wageningen University, Human and Animal Physiology

wo 7 december 2016 13:30 tot 15:00

Locatie Auditorium, building number 362
Generaal Foulkesweg 1
6703 BG Wageningen


As female reproduction is tightly linked to body energy status, it is not surprising that disturbed energy metabolism may negatively influence reproductive performance. The overall goal of this thesis was therefore to investigate the effects of an altered energy status on ovarian follicular development in more detail, using two animal models with altered energy status; a diet-induced thyroid hormone deficiency model affecting whole body metabolism, and a genetic model of lower availability of metabolic fuels (glucose, fatty acids and amino acids). The results of this thesis provide new insights in the mechanisms of ovarian follicle degeneration and show that conditions that alter metabolic fuel distribution, influence ovarian follicular development and thus female fertility.