Recent outbreaks of foot-and-mouth disease (FMD) in Northern-Africa show that the disease can easily be introduced again in regions in which FMD was under control. The outbreaks in Northern-Africa might also pose a risk to Europe. In order to fight this disease in Africa Tesfaalem Tekleghiorghis studied several aspects of FMD as Eritrean PhD student working at Central Veterinary Institute, part of Wageningen UR.
In his thesis Foot-and-mouth disease sero-surveillance in Africa and vaccine matching Tekleghiorghis describes the roles that animal husbandry, trade and wildlife play in the transmission of FMD virus. This is further supplemented with two studies to determine which FMD serotypes caused infection in Eritrea.
In the second part of his thesis he determines which methods are best suited to select vaccines strains, and if adjuvant, route of vaccination and dose can influence the vaccination response.
Control of FMD in Africa will be difficult, as the animal husbandry and trade play an important role in the dissemination of the disease. Tekleghiorghis therefore concludes that vaccines will be an important tool to control the disease in Africa, but in that case good quality vaccines with matching strains have to be used.
The work was supported both by the International Atomic Energy Agency and the Dutch ministry of economic affairs (WOT-01-003-11).