Genomic and Functional Analysis of Organohalide-Respiring Firmicutes

Promotie

Genomic and Functional Analysis of Organohalide-Respiring Firmicutes

Promovendus T Kruse Hansen
Promotor prof.dr. WM (Willem) de Vos
prof.dr. H (Hauke) Smidt
Organisatie Wageningen University, Laboratory of Microbiology
Datum

ma 30 november 2015 13:30 tot 15:00

Locatie Auditorium, building number 362
Generaal Foulkesweg 1
362
6703 BG Wageningen
0317-483592

Summary

Organohalides has been and are still used for a wide range of industrial applications. Unfortunately are many of these toxic to humans and other animals. The release of these compounds into the environment are therefore considered as an environmental problem. These compounds are often difficult to degrade and can therefore stay in the environment for long time. Some bacteria are able to degrade these, under oxygen free conditions. We have studied bacteria belonging to two different genera belonging to the phylum Firmicutes. These are Dehalobacter and Desulfitobacterium, representing two contrasting lifestyles. The former does only grow on organohalides, whereas the latter has been shown to grow on organohalides and a wide range of other substrates. We analysed and compared the genomes and proteome of representative of these two genera to obtain an improved understanding of how these bacteria have degrades these compounds, which ultimately may lead to more efficient and cheaper methods for cleaning polluted soil and groundwater.