Integrating data mining and molecular modelling for enzyme design

Speaker: Prof. Dr. Jürgen Pleiss (Institute of Technical Biochemistry, University of Stuttgard, Germany)

Organisator Laboratory of Biochemistry

vr 10 maart 2017 10:45

Locatie Helix, gebouwnummer 124
Stippeneng 4
6708 WE Wageningen
Zaal/kamer 1100
Enzymes are promising catalysts for a wide range of biocatalytic processes. However, in most cases the performance of commercially available enzymes is below the threshold of economic viability for the biocatalytic process, and it will therefore be necessary to develop an optimal biocatalyst with appropriate stability. Because protein engineers (in contrast to mechanical or electrical engineers) still lack a deep understanding of their system under investigation, trial-and-error strategies are widely used. By integrating data mining and molecular modellig, we obtain a deeper insight into the relationships between sequence, structure and functon of an enzyme family, search for promising enzyme candidates by navigating sequence space and efficiently design enzyme variants with improved properties under given process conditions.In