On the Role of Vaccine Dose and Antigenic Distance in the Transmission Dynamics of Highly Pathogenic Avian Influenza (HPAI) H5N1 Virus and its Selected Mutants in Vaccinated Animals

Promotie

On the Role of Vaccine Dose and Antigenic Distance in the Transmission Dynamics of Highly Pathogenic Avian Influenza (HPAI) H5N1 Virus and its Selected Mutants in Vaccinated Animals

Promovendus mr. I (Ioannis) Sitaras
Promotor prof.dr.ir. MCM (Mart) de Jong
Copromotor dr. BPH (Ben) Peeters
Organisatie Wageningen University, Quantitative Veterinary Epidemiology, Wageningen Institute of Animal Sciences (WIAS), Wageningen Bioveterinary Research
Datum

wo 1 november 2017 11:00 tot 12:30

Locatie Auditorium, building number 362
Generaal Foulkesweg 1
362
6703 BG Wageningen
0317-483592

Summary

One of the biggest difficulties in ensuring vaccine success against influenza viruses is the ability of the viruses to constantly evolve and avoid vaccination-induced immunity. As a consequence, vaccination against avian influenza often fails, and constant vaccine updating is too costly. In our research we examined the evolution of avian influenza viruses by establishing a novel method of selection for antigenically-different mutants. We conducted extensive transmission experiments and quantified for the first time the minimum level of immunity that animals need to have in order for a vaccine to protect them against antigenically different viruses. From our results it is clear that the antigenic differences between vaccine and virus are not the main problem in vaccine effectiveness.