What does the concept Anthropocene mean for the sciences? Do scientists need the concept to do their research? If it doesn’t change the facts why bother at all? In a situation of analytical uncertainty, there is only need for more science to deliver the facts. Simon Bush (environmental sociology) and Thom Kuyper (soil science) perform a debate about how much the natural and social science need each other in this and what that means for the Anthropocene generation of scientists, especially in Wageningen.