Promotie

Identification of oligosaccharides in human and animal milk: from composition to synthesis

Promovendus Wenyuan W (Wenyuan) Zhang MSc
Promotor prof.dr.ir. KA (Kasper) Hettinga
Copromotor dr. J (Jurgen) van Baal
Externe copromotor Prof J.P. Lyu
Organisatie Wageningen University
Datum

ma 22 mei 2023 13:30 tot 15:00

Locatie Omnia, gebouwnummer 105
Hoge Steeg 2
6708 PH Wageningen
+31 (0)317 - 484 500
Zaal/kamer Auditorium

Samenvatting (Engelstalig)

Because of the larger differences among human and animal milks, animal milk based infant formula fed infants have some health problems such as diarrhea. My PhD research is about the oligosaccharide concentrations in human and animal milks, we studied the milk oligosaccharide synthesis in cells. We first identified the significant effects of multiple factors on oligosaccharide concentrations in human milk. Moreover, oligosaccharide profile in human milk is large different with that in animal milk and camel milk has the most similar composition with human milk among animal milks. The cell culturing experiments showed additions of sugars can change milk oligosaccharide synthesis in cells by activating related enzymes. These results provide the new insights in oligosaccharide synthesis and regulations.