Mucosal immunomodulation mitigating PEDV infection in pigs: The role of antiviral factors and IgA antibodies

Samenvatting

Porcine epidemic diarrhea virus (PEDV) remains a significant challenge for the pig industry, necessitating urgent solutions. Current commercial vaccines have limitations in providing effective protection, and the lack of specific anti-viral drugs for clinical use further exacerbates the problem. As an enteric virus, PEDV predominantly targets the small intestine of pigs, leading to substantial damage to the intestinal barrier. Given the pivotal role of the mucosal immune system, particularly IgA, in defending against intestinal pathogens, there is a pressing need for immune-based strategies. This project explores novel approaches aimed at modulating intestinal IgA production and enhancing host antiviral mechanisms, offering promising avenues for the prevention and control of PEDV infection in pigs.