Prediction of transfer and half-life of pesticides/biocides in eggs

Stage

Prediction of transfer and half-life of pesticides/biocides in eggs

During incidents, like the fipronil egg contamination incident in the Netherlands in 2017, information on the transfer and half-life of a contaminant in eggs is crucial for making estimations on the time it takes before levels are below the MRL, to estimate when the eggs could to be sold again.

The aim of the project is to identify whether transfer and half-life of different pesticides/biocides in eggs, including fipronil, can be estimated by measuring the metabolic conversion of the chemicals with chicken liver S9 and predicting the partitioning in eggs based on the lipophilicity of the compound.

Based on derived in vitro kinetic data, physiologically based kinetic (PBK)-models will be made to predict the overall time course of the contamination in eggs. Outcomes will be compared with measured levels of the respective compounds in chickens and eggs available in literature.

Supervisors: Geert Stoopen, Ad Peijnenburg 

If you are interested in this topics, send your application (letter and curriculum vitae) to Ad Peijnenburg.

Time schedule