One Health suggests that protecting animal and environmental health also contributes to human health and vice versa. It also suggests that humans and animals are all worthy of protection. However, what does this imply for common measures to control zoonotic diseases, such as the culling of livestock? Wageningen University & Research philosophers explore ethical arguments for decision-making in dilemmas, in which animal welfare, personal health and public health are at odds. The goal is to strengthen the One Health approach and to contribute to quality of life of humans and animals.