Plant lipid droplets as carriers of therapeutics

Promovendus U (Umay) Vardar-Kule
Promotor dr. K (Costas) Nikiforidis
Copromotor prof.dr. JH (Harry) Bitter
Organisatie Wageningen University, Biobased Chemistry and Technology

wo 19 juni 2024 11:00 tot 12:30

Locatie Omnia, gebouwnummer 105
Hoge Steeg 2
6708 PH Wageningen
+31 (0)317 - 484 500
Zaal/kamer Auditorium


The delivery of hydrophobic molecules with therapeutic purposes is hindered by their low water solubility. Efficient delivery of these molecules to the target requires encapsulating them into a carrier. Several synthetic materials have been proposed to carry hydrophobic therapeutics; however, their biodegradability and effectiveness remain challenging. To address these challenges, there is growing interest in effective, non-toxic, biodegradable, natural materials for delivering these molecules. Plant lipid droplets (oleosomes), as nature-assembled lipid carriers, are promising alternatives to synthetic lipid-based delivery systems. Therefore, in this thesis, we aim to investigate plant lipid droplets as building blocks of nature and utilize them to carry hydrophobic molecules. The findings contribute to understanding the potential of plant lipid droplets in advanced applications.