Publication: A Heritable Antiviral RNAi Response Limits Orsay Virus Infection in Caenorhabditis elegans N2

Published on
February 27, 2014

Quite recently a virus infecting the model species C. elegans was described, opening up the possibility to study host-virus interactions.

This virus was isolated from C. elegans nematodes found in France, and named Orsay virus, after its place of discovery. As little is known yet about the infection, we set out to explore how the virus infection progresses. We infected the nematodes at various life-stages and found that in the commonly used strain Bristol N2, the infection is limited due to a heritable antiviral RNA interference response. Thus, the offspring of infected nematodes is less susceptible to virus infection than their parents were.

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