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Publication: Natural genetic variation differentially affects the proteome and transcriptome in C. elegans

Gepubliceerd op
9 maart 2016

An important question is how genetic variation at the RNA level translates into variation in protein abundance. We analyzed the proteome and transcriptome in two genetically divergent strains of the nematode C. elegans.

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The differentially expressed proteins were enriched for genes that function in insulin-signaling and stress response pathways, underlining strong divergence of these pathways. The protein abundance of the two wild-type strains correlates more strongly than protein abundance versus transcript abundance within each wild type. Our findings indicate that in C. elegans only a fraction of the changes in protein abundance can be explained by the changes in mRNA abundance.