Carla Araya-Cloutier received the prestigious VENI-grant to kick-start her research on natural efflux pump inhibitors to combat antibiotic resistance. Her proposal, "The wisdom of plants: Blocking pathogen's emergency exit to restore antimicrobial efficiency" was awarded a grant.
Carla's project aims at investigating natural efflux pump inhibitors. Bacteria can survive antibiotics by pumping them out of their cells using efflux pumps. Stressed plants produce compounds that block these efflux pumps. To restore antibiotics’ efficiency, researchers will propose novel efflux pump blockers from stressed plants, and study their operation with the aid of innovative computer modelling tools.
The Veni grants are awarded annually by the NWO to outstanding researchers who have just finished their PhDs. They are selected on the basis of the following criteria: quality of the researcher, innovative character of their research, expected scientific impact and possibilities for knowledge validation.
A total of 1151 researchers submitted research proposals to the NWO. 166 of them were awarded a grant, including nine WUR scientists
Toward developing a yeast cell factory for the production of prenylated flavonoids
Journal of Agricultural and Food Chemistry 67 (2019)49. - ISSN 0021-8561 - p. 13478 - 13486.
QSAR of 1,4-benzoxazin-3-one antimicrobials and their drug design perspectives
Bioorganic and Medicinal Chemistry 26 (2018)23-24. - ISSN 0968-0896 - p. 6105 - 6114.
QSAR-based molecular signatures of prenylated (iso)flavonoids underlying antimicrobial potency against and membrane-disruption in Gram positive and Gram negative bacteria
Scientific Reports 8 (2018). - ISSN 2045-2322
Antibacterial prenylated stilbenoids from peanut (Arachis hypogaea)
Phytochemistry Letters 28 (2018). - ISSN 1874-3900 - p. 13 - 18.
Rapid membrane permeabilization of Listeria monocytogenes and Escherichia coli induced by antibacterial prenylated phenolic compounds from legumes
Food Chemistry 240 (2018). - ISSN 0308-8146 - p. 147 - 155.
Antibacterial prenylated isoflavonoids and stilbenoids : quantitative structure-activity relationships and mode of action
Wageningen University. Promotor(en): H. Gruppen, co-promotor(en): J.P. Vincken; H.M.W. den Besten. - Wageningen : Wageningen University - ISBN 9789463430364 - p.
Structural basis for non-genuine phenolic Acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily
PLoS ONE 12 (2017)3. - ISSN 1932-6203
The position of prenylation of isoflavonoids and stilbenoids from legumes (Fabaceae) modulates the antimicrobial activity against Gram positive pathogens
Food Chemistry 226 (2017). - ISSN 0308-8146 - p. 193 - 201.