obesitas

Project

Proteins fighting obesity

Obesity is a social health issue which is rapidly becoming a serious problem in the Western world. Obesity is one of the risk factors in metabolic syndrome.

Goal

The goal of this project is to study the effects of dietary fibre and protein hydrolysate on the gene expression profiles of cell lines in relation to satiety. This study is part of larger projects (IPOP Food, Fibre and Health and PIDON Obesitas) focusing on research on a range of related topics from food ingredients to human studies.

Intended result

The results are as follows:

  • Sets of differential genes which have been expressed (after incubation of various fibre and protein fractions with Hutu-80 and STC-1 cells).
  • Analyses of relationships of these sets of genes with satiating effects in vivo. For instance, have any peptide hormones or their receptors been expressed which are linked to satiation?
  • Comparisons of the results of these analyses with the results of human in vivo studies on satiation with fibres or proteins. In this way it will be possible to determine the value of the in vitro method for characterising fibre and protein fractions in relation to satiation.

Method

In the final year of both the IPOP project Food, Fibre & Health and the PIDON project Obesitas, fibre fractions and protein hydrolysates will be incubated (with Hutu-80 and STC-1 cells).

Analyses of differential genes which have been expressed will be compared with the results of human in vivo studies carried out within both projects.