Adverse drug reactions from single drugs or drug-drug interactions are evaluated during the drug development and approval process. Systematic research on drug-nutrient interactions (DNIs) however is scarce. The Nutrition Alliance Gelderse Vallei, a collaboration of Wageningen University and Hospital Gelderse vallei, addresses this knowledge gap in her project PanDeMics.
Main objective of PanDeMics is to investigate associations between drug use and nutritional status. Research questions are about the predictive value of polypharmacy and use of specific drug groups on deficiency of specific micronutrients and risk of malnutrition. Tools are literature research followed by cross-sectional analyses of patient data of the geriatric outpatient clinic of Hospital Gelderse Vallei. In this study population, polypharmacy is highly prevalent.
At the moment, a first review about drug use and vitamin D status has been published (1); a cross-sectional study about this subject is being submitted. The same is planned for vitamin B12, folic acid and magnesium. Furthermore, drug use as indicator of malnutrition risk (Mini Nutrition Assessment scores) and mortality will be investigated.
Food for the Aging Population
Cambridge : Woodhead Publishing - ISBN 9780081003480 - p.
Geneesmiddelgebruik, ondervoeding en deficiënties bij ouderen
MFM- praktijkgerichte nascholing over farmacotherapie (2016)editie 2. - ISSN 0168-7670
Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients
European Journal of Clinical Pharmacology (2016). - ISSN 0031-6970 - p. 605 - 614.
The association between drugs frequently used by the elderly and vitamin D blood levels: a review of observational and experimental studies
Drugs & Aging 31 (2014)2. - ISSN 1170-229X - p. 111 - 123.
More research: Drug-nutrient interactions in older persons