This thesis analysed the effects of expected climate change impacts on and the options for adaptation of pangasius farming in the Mekong Delta. Sea level rise of more than 75 cm will reduce the time-window for pangasius culture in coastal areas due to salinity levels, while further inland flooding is a larger threat. The technical efficiency of downstream farms was higher compared to the upstream and midstream farms due to lower energy costs and stocking once a year at a lower density, but these reduced the scale efficiency of farms affected by salinity intrusion. Upstream and midstream farms needed to pump water and stocked at least 3x in two years. Next to dike enforcements, breeding a salinity tolerant pangasius strain is an efficient adaptation tool. As farmer’s education level and past experience with flooding or salinity intrusion have a positive effect on technical efficiency he advises among others to increase information on climate change as less than half of the farmers actively sought suitable adaptation measures.