Discovery of Inhibitors of Bacterial Histidine Kinases

Promovendus NR (Nadya) Velikova PhD
Promotor prof.dr. JM (Jerry) Wells
Copromotor dr. A Marina
Organisatie Wageningen University, Host Microbe Interactomics

vr 7 november 2014 11:00 tot 12:30

Locatie Auditorium, building number 362
Generaal Foulkesweg 1
6703 BG Wageningen

The thesis is on novel antibacterial drug discovery ( Using structure-based and fragment-based drug discovery approach, we have identified small-molecule histidine-kinase inhibitors with antibacterial effect against multi-drug resistant strains, including clinical isolates of multi-drug resistant bacteria such as MRSA. Furthermore, we have shown broadening of the antibacterial spectrum and lowering the toxicity of the histidine-kinase inhibitors using nanoparticles. The results open up exciting possibilities for development of novel antibacterial(nano)medicines.