Eva Dóró - The characterization of the role of soluble and membrane bound TNF during infections in zebrafish
Since May 2012, Eva joined the Cell Biology and Immunology group, appointed on an International Training Network (ITN) project (FishforPharma). She will work with Maria Forlenza and Geert Wiegertjes on the characterization of the role of soluble and membrane bound TNF during infections in zebrafish.
Since May 2012, Eva joined the Cell Biology and Immunology group, appointed on an International Training Network (ITN) project (FishforPharma). She will work with Maria Forlenza and Geert Wiegertjes on the characterization of the role of soluble and membrane bound TNF during infections in zebrafish. Previous work in the group has shown that membrane-TNF-alpha (mTNFa) can play a crucial protective role during trypanoplasma infections. To further elucidate the mechanisms of action of mTNFa, Eva will use the zebrafish model which offers several technological advantages among which morpholino technology for transient gene knockdown in embryos up to the larval stages; in vivo imaging of host-pathogen interactions, for example using transgenic reporter lines expressing fluorescent proteins in different immune cell types.
