Being overweight literally means having extra weight, in particular, a large amount of excess fat. This changes the metabolism of adipose tissue resulting in chronic tissue inflammation. In this study we investigated several factors that may affect adipose tissue metabolism such as diet composition, ambient temperature, and oxygen reduction. Here, the mouse was used as a model.
Remarkable was the finding that a diet history of healthy or unhealthy eating did not influence the current body weight and functioning of the adipose tissue. This was entirely determined by the last consumed diet. For humans, this could mean that following a healthy diet is the answer to the obesity problem.
From the other studies described in this thesis it appears that there are many more factors that influence the functioning of adipose tissue, sometimes even unexpectedly. This cumulatively shows that unraveling the complexities of the derailment of fat is essential to provide a counterbalance to the obesity epidemic.