Iodine deficiency has been recognized as a major cause of hypothyroidism and adverse health consequences in both mothers and children. Iodine supplementation of mildly iodine-deficient pregnant women has been recommended worldwide; however, long-term benefit and safety of iodine supplementation in this population group is uncertain.
In this multi-center randomized controlled trial, either iodine supplementation or placebo has been administered to 323 pregnant women living in Bangalore, India, and to 516 pregnant women living in Bangkok, Thailand. Women were enrolled before teh 14th week of gestation. We measured urinary iodine concentration, thyroid volume and thyroid function of the mothers during pregnancy, at delivery and postpartum. Newborn thyroid volume, thyroid function indicators and urinary iodine concentration were measured with regular intervals up till 2 years of age. At 6 weeks, infant behaviour was assessed with the Neonatal Behavioral Assessment Scales. Cognitive and psychomotor performance was evaluated by the Bayleys Scale of Development at 1 and 2 years of age. Follow up measurements are performed at the age of 5-6 years with the Wechsler Preschool and Primary Scale of Intelligence.
High Prevalence of Maternal Hypothyroidism Despite Adequate Iodine Status in Indian Pregnant Woman in the First Trimester
Thyroid 24 (2014)9. - ISSN 1050-7256 - p. 1419 - 1429.
The iodized salt programme in Bangalore, India provides adequate iodine intakes in pregnant women and more-than-adequate iodine intakes in their children
Public Health Nutrition 18 (2015)3. - ISSN 1368-9800 - p. 403 - 413.
Overweight increases risk of trimester hypothyroxinaemia in iodine-deficient pregnant woman
Maternal and Child Nutrition 10 (2014)1. - ISSN 1740-8695 - p. 61 - 71.
Iodine deficiency, thyroid function and hearing deficit: a review
Nutrition Research Reviews 26 (2013)2. - ISSN 0954-4224 - p. 110 - 117.
Iodine supplementation in pregnancy and its effest on child cognition
Journal of Trace Elements in Medicine and Biology 26 (2012)2-3. - ISSN 0946-672X - p. 134 - 136.
Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development
Best Practice & Research Clinical Endocrinology & Metabolism 24 (2010)1. - ISSN 1521-690X - p. 29 - 38.
Urinary Iodine Concentrations Indicate Iodine Deficiency in Pregnant Thai Women but Iodine Sufficiency in Their School-Aged Children
The Journal of Nutrition 139 (2009)6. - ISSN 0022-3166 - p. 1169 - 1172.