PhD defence Henry Kariithi: "Glossina hytrosavirus control strategies in tsetse fly factories: Application of infectomics in virus management"

This PhD research has investigated various molecular aspects on the biology and infection of the tsetse fly virus Glossina hytrosavirus (family Hytrosaviridae). The ultimate research goal was to develop strategies to control the virus in tsetse fly production factories.

Promovendus HM (Henry) Kariithi MSc
Promotor prof.dr. JM (Just) Vlak
prof.dr. MM (Monique) van Oers
Copromotor dr AMM Abd-Alla , dr GA Murilla
Organisatie Wageningen University, Laboratory of Virology

wo 20 november 2013 16:00 tot 17:30

Locatie Auditorium, building number 362
Generaal Foulkesweg 1
6703 BG Wageningen
As an insect host metamorphoses to adulthood, vertical transmission of an insect virus becomes epizootically more important than horizontal transmission.
Henry Muriuki Kariithi

The goal was accomplished by a series of experiments designed to: (i) determine epidemiology and diversity of the virus; (ii) identify which of the viral genes are expressed into proteins, (iii) what the functions of these proteins are, and to what extent they contribute to the structure and pathobiology of the virus; (iv) investigate interactions between tsetse, the virus and other micro-organisms, and how these interactions influence the viral infection; and (v) develop protocols to control the virus in tsetse fly production factories. The research led to successful control of the virus in tsetse production factories, thus setting centre stage for future research and an opportunity to revive tsetse and trypanosomiasis control strategies in sub-Sahara Africa.