On October 10th the Wageningen Centre for Systems Biology (WCSB) will organise a seminar on systems biology. The seminar is free, will take an hour and will be followed by drinks. No registration is necessary, so feel free to come by!
Dr. Roeland Merks, team leader Biomodelling and Biosystems Analysis, Life Sciences, Centrum Wiskunde & Informatica and Netherlands Institute for Systems Biology, Amsterdam, Mathematical Institute, Leiden University, Leiden
"Multiscale modeling of biological development and disease: blood vessel development, gut microbiota and tumor progression"
How individual cells cooperate to build and maintain functioning multicellular organisms is one of the most intriguing questions in biology. In many multicellular systems the molecular signals in cell-cell interactions have been very well characterized, but it is poorly understood how these local interactions are responsible for the higher-level phenomena in multicellular organisms, including organogenesis, tumor growth and microbial consortia. Cell-based computational models are helpful tools in answering that question. These models take as input a set of key modules of the biological system, e.g. cells, extracellular materials and metabolites, and a set of rules describing their validated or hypothetical physical and chemical interactions. Using computer simulation or mathematical analysis, the model can then show what--often non-intuitive--dynamic collective behavior can follow from the cell-cell interactions. In this talk I will give an overview of the cell-based modeling efforts in my group, ranging from models describing the mechanical cell-ECM interactions during blood vessel development, to multiscale modeling of the gut microbiota and tumor progression.
For more information please check the website: http://biomodel.project.cwi.nl.
More information about WCSB and the 14 different projects can be found on the website www.wur.nl/systemsbiology.