Call for partners: Paladin – Postbiotics to mitigate low-grade inflammation

Postbiotics, the new kid on the block

Postbiotics are the new kid on the block in the field of managing gut health. While probiotics, prebiotics, and synbiotics are widely accepted, postbiotics may offer new and additional benefits for health. They can be obtained through product fermentation, are less sensitive to process conditions, and have a longer shelf life. Postbiotics may be a promising strategy to support gut health and reduce low-grade inflammation, and potentially help to prevent chronic diseases.

Postbiotics put to the challenge

In this project, we would like to investigate the effects of postbiotics on low-grade inflammation, intestinal permeability, and immune modulation. To achieve this, we will perform human challenge tests, ex vivo immune and microbiome assays, and in vitro tests in order to:

• Test ability of postbiotic products to prevent gut permeability and mitigate low-grade inflammation in response to an acute high fat challenge test in human pilot studies in combination with ex vivo immune assays.
• Optimise and validate in vitro postbiotic screening models to gain insight in the mechanisms of action
• Investigate longer term effects of one or two selected of oral supplementation with selected postbiotics on low-grade inflammation, intestinal permeability and immune support in a human trial

Eager to join?

We are looking for food ingredient companies and end producers of postbiotic products that want to understand better the potential health effects of postbiotics and are also interested to support the development, improvement, and validation of in vivo, in vitro, and ex vivo models to assess those effects.