
African horse sickness
African horse sickness (AHS) is a highly fatal, non-contagious, infectious disease, of horses, mules and donkeys caused by the AHS virus. Wageningen Bioveterinary Research conducts research on this disease.
Infection
This orbivirus is transmitted between hosts by small biting insects known as "midges" (Culicoides species). The clinical signs are usually more severe in horses than other equids and may vary depending on what form of the disease is present.
Zebras may be infected with AHS virus but do not exhibit clinical signs. Carnivores such as dogs and big cats can also be infected with AHSV after eating infected meat. And AHSV antibodies have been found in elephants and rhinoceros. But the importance of these species for the transmission of the virus remains unclear.
Outbreaks
The virus exists as nine serotypes, all of which are endemic in sub-Saharan Africa. Outbreaks of African horse sickness have occurred as far north as Spain and Portugal and as far east as India and Pakistan, but it has not persisted in these regions. Recent outbreaks of AHS in Spain and Portugal were probably related to imports of infected zebras from southern Africa.
Spread of African horse sickness
The disease may be spread via the movement of infected equids but transmission is also promoted by climatic conditions which favour high populations of carrier insects (vectors). These insects can also be spread over long distances by wind dispersal.
Publications
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Safety and efficacy of inactivated African horse sickness (AHS) vaccine formulated with different adjuvants
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African Horse Sickness Virus
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Comparing Culicoides biting rates in horses and cattle in The Netherlands : potential relevance to African horse sickness epidemiology
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Diagnostic DIVA tests accompanying the Disabled Infectious Single Animal (DISA) vaccine platform for African horse sickness
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African horse sickness virus (AHSV) with a deletion of 77 amino acids in NS3/NS3a protein is not virulent and a safe promising AHS Disabled Infectious Single Animal (DISA) vaccine platform
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Structural protein VP2 of African horse sickness virus is not essential for virus replication in vitro
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Comparative Risk Analysis of Two Culicoides-Borne Diseases in Horses : Equine Encephalosis More Likely to Enter France than African Horse Sickness
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Diel activity and preferred landing sites in Culicoides biting midges attacking Fjord horses
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Quantitative analysis of the probability of introducing equine encephalosis virus (EEV) into The Netherlands
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Requirements and comparative analysis of reverse genetics for bluetongue virus (BTV) and African horse sickness virus (AHSV)