Education at the division of Toxicology

Within this research theme, we work on the following topics:

• Alternative testing strategies to quantify the toxicity of pyrrolizidine alkoloid N-oxides
• Risk assessment of aphrodisiac herbal products from Ghanaian market
• A novel approach for the exposure and risk assessment of human systemic exposure to organophosphate pesticides via food in the Western and Chinese population

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Within this research theme, we work on the following topics:

• Absorption, metabolism and biological effects of furocoumarins and consequences for their risk assessment
• The role of stability, repair and mutagenicity in the relative hazards and risks of DNA adducts formed by food-borne liver carcinogens of variable carcinogenic potential
• Mode of action-based risk assessment of combined exposure to mycotoxins in maize and maize products
• In vitro metabolism and genotoxicity of naked versus alkylated PAH that may be present in mineral oils

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Within this research theme, we work on the following topics:

• Alternative testing strategies for characterising the development toxicity of different types of polycyclic aromatic hydrocarbons (PAHs) present in petroleum substances
• Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
• The role of the gut microbiota in the toxicity and risk assessment of food-borne chemicals
• The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone
• Development of a novel, interdiciplinary model to study interactions between foodborne xenobiotics, the intestinal microbiome and the intestinal epithelium
• Influence of intestinal microbial metabolism on the biological activity of flavonoids from herbel teas and Traditional Chinese Medicine (TCM)
• The effects of food contaminants on gut microbiota and host plasma metabolomics and related health effects

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Within this research theme, we work on the following topics:

• Alternative testing stategies for elucidating the metabolic capacity of the intestinal microbiome
• Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
• The role of the gut microbiota in the toxicity and risk assessment of food-borne chemicals
• The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone
• Development of a novel, interdiciplinary model to study interactions between foodborne xenobiotics, the intestinal microbiome and the intestinal epithelium
• Influence of intestinal microbial metabolism on the biological activity of flavonoids from herbel teas and Traditional Chinese Medicine (TCM)
• The effects of food contaminants on gut microbiota and host plasma metabolomics and related health effects

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Within this research theme, we work on the following topics:

• Interactive effect of exposure to low levels of nanomaterials on the toxicity of environmental chemicals
• Oxidative stress effects of heavy metals on the length of telomeres
• Occurrence of resistance genes in small mammals in agricultural areas
• Effects of lead on immune status of waterfowl and implications for dispersion of avian influenza
• Development of PBK mode for pesticides/metals in small mammals
• Effects of exposure scenarios on the toxicity of environmental contaminants on benthic marine organisms

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