Antiviral treatment can be used to treat patients with viral infections or alternatively prevent infection in individuals at risk from getting a severe disease. Wageningen Bioveterinary Research (WBVR) can test the efficacy of antivirals against viruses.
Antivirals in the broad sense can function by:
- Targeting viral proteins directly
- Targeting host cell factors that are essential for virus replication
- Enhancing the function of the immune system in its reaction toward the virus
Since antiviral development is often a process of trial and error, in vitro efficacy testing is an important step to identify the most promising candidates for further development. Due to the expertise that Wageningen Bioveterinary Research (WBVR) has, we can offer broad services to test the efficacy of antivirals against a variety of veterinary and zoonotic viruses and in different cell lines in vitro.
In these tests, we can determine the level of viral replication in presence or absence of antivirals; determine the IC50 of the antiviral compounds; or perform virus neutralization assays with compounds that have neutralizing capacity. In addition WBVR can determine efficacy of disinfecting agents against viruses.
Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is currently causing a pandemic outbreak. Infections with this virus result in Corona Virus Disease 2019 (COVID-19) in humans, characterized with symptoms such as fever, dry cough, fatigue and loss of smell and taste. Antivirals can suppress growth of this coronavirus. We offer a dedicated in vitro model to test efficacy of antiviral compounds in Vero E6 cells, to select candidates that are active against SARS-CoV-2. This can be followed up by in vivo testing in our hamster model.
Contact our expert
Please feel free to contact the expert of our contract research organization (CRO) to inform about testing your antivirals: