African Horse Sickness is an infectious, non-contagious, arthropod-borne disease of Equidae caused by African horse sickness virus transmitted by biting culicoides midges. African Horse Sickness is endemic in Africa but outbreaks outside the African continent have been reported. The disease is characterized by changes in respiratory and circulatory functions and exhibits different forms. The mortality is >90% for naïve domestic horses. In contrast, infected zebra and African donkey display mild or no clinical signs and a mortality of 5%–10%. Nine serotypes of African horse sickness virus have been recognized showing no or poor cross-protection with each other.