Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm childeren is asosiated with airway remodeling genes and innate immune genes

Siezen, C.L.E.; Hodemaekers, H.M.; Ermers, M.J.; Doornbos, G.; Slot, R. van 't; Wijmenga, I.C.; Houwelingen, H.C.; Kimpen, J.L.L.; Kimman, T.G.; Hoebee, B.; Janssen, R.


Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children