Foot-and-mouth disease
Foot-and-mouth disease (FMD) is a contagious viral disease that can spread very rapidly of cloven-hoofed animals. Among these are domestic animals such as cattle, water buffalo, sheep, goats and pigs, as well as antelope, bison and other wild bovids, including deer. Wageningen Bioveterinary Research conducts research on this disease.
The disease is caused by apicornavirus. There are seven 'serotypes' of FMD virus, each producing the same symptoms, and only distinguishable in the laboratory.
Clinical signs
Foot-and-mouth disease causes fever, followed by the development of vesicles (blisters) chiefly in the mouth and on the feet. Young animals can die due to infection of the heart, pregnant animals can abort and animals used for traction cannot work when they are ill. The disease has a huge economic impact on production, mainly due to loss in milk production but also due to abortions, the death of young animals, and the cost for veterinary care.
Spread of foot-and-mouth disease
Foot-and-mouth disease is endemic in large parts of Asia, Africa, the Middle East and South America. In parts free of FMD like Europe sporadic introduction of the disease do occur.
Economic impact
In countries were traction is important the loss of traction can cause huge losses when e.g. the fields cannot be plowed. Outbreaks of foot-and-mouth disease can lead to trade disruption, because countries free of the disease will not accept animals and animal products from countries that have FMD.
Publications
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Protection in sheep against heterologous challenge with serotype Asia-1 foot-and-mouth disease virus using high potency vaccine
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Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate
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A foot-and-mouth disease SAT2 vaccine protects swine against experimental challenge with a homologous virus strain, irrespective of mild pathogenicity in this species
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Bayesian inference of epidemiological parameters from transmission experiments
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Isolation of single-domain antibody fragments that preferentially detect intact (146s) particles of foot-and-mouth disease virus for use in vaccine quality control
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Protective effects of high-potency FMDV O<sub>1</sub> Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination
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Predicting the ability of preclinical diagnosis to improve control of farm-to-farm foot-and-mouth disease transmission in cattle
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Efficacy of a high potency O<sub>1</sub> Manisa foot-and-mouth disease vaccine in cattle against heterologous challenge with a field virus from the O/ME-SA/Ind-2001 lineage collected in North Africa
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Ensemble modelling and structured decision-making to support Emergency Disease Management
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Foot-and-Mouth Disease Seroprevalence in Cattle in Eritrea
