
Newcastle disease
Newcastle disease (ND) is a contagious and viral disease affecting many species of birds. ND is caused by a virus of the family Paramyxoviridae. Wageningen Bioveterinary Research conducts research on this disease.
Effects
Members of this virus family have a single stranded, linear, RNA. Severity of the disease is extremely variable from subclinical until high mortality depending on the strain of virus, species and age of bird, concurrent disease, and pre-existing immunity. Virulent strain of the Newcastle disease virus cause severe disease of the digestive, respiratory and/or nervous systems in particular in susceptible domestic poultry.
Transmission
In cage and aviary birds, and wild birds the outcome of the disease depends much more on the type of bird. A death rate of almost 100 percent can occur in unvaccinated poultry flocks. The disease is transmitted through infected birds' droppings and secretions from the nose, mouth, and eyes or indirect by exposure to materials contaminated with these secretions. The incubation period of the disease in poultry flocks ranges from 2 to 15 days.
Publicaties
2020
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Molecular and virological characterization of the first poultry outbreaks of Genotype VII.2 velogenic avian orthoavulavirus type 1 (NDV) in North-West Europe, BeNeLux, 2018
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Development of an effective and stable genotype-matched live attenuated newcastle disease virus vaccine based on a novel naturally recombinant malaysian isolate using reverse genetics
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Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
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Genotype Diversity of Newcastle Disease Virus in Nigeria : Disease Control Challenges and Future Outlook
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An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease
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Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry : The Current and Emerging Perspectives
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Recombinant Newcastle disease viruses with targets for PCR diagnostics for rinderpest and peste des petits ruminants
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Rescue of recombinant Newcastle disease virus : current cloning strategies and RNA polymerase provision systems
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Rescue of recombinant Newcastle disease virus : a short history of how it all started
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Construction and Application of Newcastle Disease Virus-Based Vector Vaccines