Newcastle disease (ND) is a contagious and viral disease affecting many species of birds. ND is caused by a virus of the family Paramyxoviridae. Wageningen Bioveterinary Research conducts research on this disease.
Members of this virus family have a single stranded, linear, RNA. Severity of the disease is extremely variable from subclinical until high mortality depending on the strain of virus, species and age of bird, concurrent disease, and pre-existing immunity. Virulent strain of the Newcastle disease virus cause severe disease of the digestive, respiratory and/or nervous systems in particular in susceptible domestic poultry.
In cage and aviary birds, and wild birds the outcome of the disease depends much more on the type of bird. A death rate of almost 100 percent can occur in unvaccinated poultry flocks. The disease is transmitted through infected birds' droppings and secretions from the nose, mouth, and eyes or indirect by exposure to materials contaminated with these secretions. The incubation period of the disease in poultry flocks ranges from 2 to 15 days.
Virulence of pigeon paramyxovirus type 1 does not always correlate with the cleavability of its fusion protein
A review of RT-PCR technologies used in veterinary virology and disease control: sensitive and specific diagnosis of five livestock diseases notifiable to the World Organisation for Animal Health
Activation of human T cells by a tumor vaccine infected with recombinant Newcastle disease virus producing IL-2
Herd immunity to Newcastle disease virus in poultry by vaccination