Nanochemical Biology (dr. Bauke Albada)

Research & Teaching summary

My research explores the boundaries between Chemistry and Biology using tailor-made (semi-)synthetic molecular tools. We are proud of the fact that we precisely tailor our molecules to optimally interact with the biological processes that were study. My research interest spans a range of topics, including the site-selective modification of proteins using chemical and nanochemical methods, unravelling of the molecular mechanism by which omega-3 unsaturated fatty acids interact with human inflammation pathways, and the identification of novel methods to combat bacterial infections

We collaborate with various groups within the Wageningen University & Research community, but also with other groups in The Netherlands and abroad. Our work has been published in leading chemistry journals like J. Am. Chem. Soc., Angew. Chem., Chem. Sci., and J. Org. Chem..

I am coordinator and main teacher of the BSc-level course Bio-Organic Chemistry (ORC-20306), and the MSc-level course Chemical Biology: Exploring Biology with Small Molecules (ORC-50803). On top of that, I am instructor in the courses Organic Chemistry 1 & 2 (ORC-12803 & ORC-12903), Environmental Analysis Techniques (SOQ-33806), VLAG Advanced Chemistry, and VLAG Advanced Organic Chemistry.

Teaching Philosophy

I see teaching as a team-effort that involves a dynamic interaction between teacher and students. Of course, in large classes, the interaction is usually less than in smaller groups. Nevertheless, I’m continuously seeking interaction with students by asking questions, invoking responses, and giving them (small) assignments. Within this dynamic interaction, I’m trying to establish individual needs of students so that I can tailor the message that needs to come across. In this way, new developments in the field can be incorporated in the course, and the student is kept up-to-speed with the latest scientific developments.

The Group

Bauke Albada (group leader), Ian de Bus (PhD student), Jorick Bruins (PhD student co-supervised with Floris van Delft), Digvijay Gahtory (PhD student co-supervised with Maarten Smulders), Rickdeb Sen (PhD student co-supervised with Han Zuilhof), Judith Firet (technician), Rob Bakker (HLO student), Robin van Veen (HLO student), Viktor Meijs (BSc student).

Bauke Albada on: Google Scholar, OrcID.

Details on current research topics

  • Fishing for endogenous inhibitors of inflammation derived from ‘omega-3 fatty acids’; unravelling the interactions between N-docosahexaenoylethanolamide and cyclooxygenase COX-2 (PhD student: Ian de Bus) (in collaboration with Michiel Balvers and Renger Witkamp).
  • Development of the next generation of antibody-drug conjugates (PhD student: Jorick Bruins) (in collaboration with Floris van Delft).
  • Development of PNA-based biosensors for the detection of genetic material from pathogens (PhD student: Digvijay Gahtory) (in collaboration with Han Zuilhof and Roger Stromberg).
  • Localized attachment of DNAzymes in microchannels of glass-based microfluidic systems (PhD student: Rui Rijo da Costa Carvalho) (in collaboration with Han Zuilhof).
  • Covalent attachment of DNA nanostructures on mica (PhD students: Rickdeb Sen and Digvijay Gahtory) (in collaboration with Han Zuilhof).
  • Covalent attachment of DNAzymes on marine / surgical grade stainless steel (PhD student: Medea Kosian) (in collaboration with Han Zuilhof).
  • Aptamer-functionalized conductive polymers as soluble biosensors for proteins (BSc student: Viktor Meijs) (in collaboration with Joris Sprakel).

International collaborations:

  • Metal Ion Complex/Aptamers Conjugates: Nucleoapzymes Mimicking Catechol Oxidase (in collaboration with Itamar Willner, Jerusalem, Israel).
  • The scent of predation: Identification of an aquatic infochemical - the Chaoborus kairomone (in collaboration with Ralph Tollrian, Bochum, Germany).
  • Organometallic-antimicrobial peptides (in collaboration with Nils Metzler-Nolte and Julia Bandow, Bochum, Germany).

Selected Publications (* denotes corresponding author)

  1. Bauke Albada* and Nils Metzler-Nolte*, ‘Organometallic-Peptide Bioconjugates: Synthetic Strategies and Medicinal Applications’, Chem. Rev., 2016. ASAP. DOI: 10.1021/acs.chemrev.6b00166
  2. Dora Balogh, Miguel Angel Aleman Garcia, H. Bauke Albada*, Itamar Willner*, ‘Programmed Synthesis by Stimuli-Responsive DNAzyme-Modified Mesoporous SiO2 Nanoparticles’, Angew. Chem. Int. Ed., 2015, 54, 11653-11656. DOI: 10.1002/anie.201501777
  3. Natalie Enkin, Fuan Wang, Etery Sharon, H. Bauke Albada, Itamar Willner*, ‘Multiplexed Analysis of Genes Using Nucleic Acid-Stabilized Silver-Nanocluster Quantum Dots’, ACS Nano, 2013, 8, 11666-11673. DOI: 10.1021/nn504983j
  4. Martin Strack, Nils Metzler-Nolte, H. Bauke Albada*, ‘C-Terminal Acetylene Derivatized Peptides via Silyl-Based Alkyne Immobilization’, Org. Lett., 2013, 15, 3126-3129. DOI: 10.1021/ol401332r
  5. Martin Strack, Sina Langklotz, Julia E. Bandow, Nils Metzler-Nolte, H. Bauke Albada*, ‘Silyl-Based Alkyne-Modifying Linker for the Preparation of C-Terminal Acetylene-Derivatized Protected Peptides’, J. Org. Chem., 2012, 77, 9954-9958. DOI: 10.1021/jo302305d

Former Member

Kenan Ozbasi (BSc student, March-July 2016).