Thesis Topics

BSc Thesis

Topics 1-4: contact Hans Bouwmeester

Topic 5: contact Nico van den Brink

MSc Thesis Topics

The thesis topics at the Division of Toxicology are divided in 5 major topics:

1) Risk assessment of herbal food supplements and teas. Contact: Prof. Ivonne Rietjens

2) Mode of action of food-borne (natural) toxins. Contact: Prof. Ivonne Rietjens

3) Alternatives to animal testing. Contact: Dr. Hans Bouwmeester

4) The role of the gut microbiota in the toxicity of food-borne chemicals. Contact: Prof. Ivonne Rietjens

5) Environmental toxicology. Contact: Dr. Nico van den Brink

Please note that apart from the projects given below, there also possibilities for performing a thesis on a risk assessment based on literature studies at the Toxicology department.

Following next you can already find an overview of the different topics for each of the 5 themes:

1) Risk assessment of herbal food supplements and teas.

  • Alternative testing strategies to quantify the toxicity of pyrrolizidine alkoloid N-oxides
  • Risk assessment of aphrodisiac herbal products from Ghanaian market
  • Development of a novel approach for the exposure and risk assessment of human systemic exposure to organophosphate pesticides via food in the Western and Chinese population

2) Mode of action of food-borne (natural) toxins.

  • Absorption, metabolism and biological effects of furocoumarins and consequences for their risk assessment
  • The role of stability, repair and mutagenicity in the relative hazards and risks of DNA adducts formed by food-borne liver carcinogens of variable carcinogenic potential
  • Mode of action-based risk assessment of combined exposure to mycotoxins in maize and maize products
  • In vitro metabolism and genotoxicity of naked versus alkylated PAH that may be present in mineral oils

3) Alternatives to animal testing.

  • Alternative testing strategies for characterising the development toxicity of different types of polycyclic aromatic hydrocarbons (PAHs) present in petroleum substances
  • Role of substituted Polycyclic Aromatic Hydrocarbons in Developmental Toxicity of Petroleum Substances
  • Novel testing strategies within the framework of REACH for characterising the developmental toxicity of different types of pollycyclic aromatic hydrocarbons (PAHs) preent in petroleum substances
  • Predicting in vivo toxicity by combining in vitro testing and generic physiologically based kinetic (PBK) modelling approach
  • Non-animal testing of human risk of plastic associated chemicals
  • Evaltuate potential effects of nanamedicine or nanobiomaterials released from Advanced Therapy Medicinal Products and/or Medical Devices
  • Development of combined in vitro-in silico methods for the risk assessment of pesticide mixtures
  • Novel in vitro assays that enable incorporation of urinary and biliary excretion in generic physologically based kinetic (PBK) models
  • Assasment of phospho-signaling in retinal tissues in vitro and in vivo by kinase activity profiling
  • Towards next generation risk assesment to inform human-relevant safe levels of chemical exposure: integrated in vitro-in silico approaches for chemicals with putative (anti)androgenic effects
  • Effect of exposure to xenobiotics on bile acid composition and its consequences along the intentine-livir-axis

4) The role of gut microbiota in the toxicity of food-borne chemicals.

  • Alternative testing stategies for elucidating the metabolic capacity of the intestinal microbiome
  • Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
  • The role of the gut microbiota in the toxicity and risk assessment of food-borne chemicals
  • The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone
  • Development of a novel, interdiciplinary model to study interactions between foodborne xenobiotics, the intestinal microbiome and the intestinal epithelium
  • Influence of intestinal microbial metabolism on the biological activity of flavonoids from herbel teas and Traditional Chinese Medicine (TCM)
  • The effects of food contaminants on gut microbiota and host plasma metabolomics and related health effects

5) Environmental toxicology.

  • Interactive effect of exposure to low levels of nanomaterials on the toxicity of environmental chemicals
  • Oxidative stress effects of heavy metals on the length of telomeres
  • Occurrence of resistance genes in small mammals in agricultural areas
  • Effects of lead on immune status of waterfowl and implications for dispersion of avian influenza
  • Development of PBK mode for pesticides/metals in small mammals
  • Effects of exposure scenarios on the toxicity of environmental contaminants on benthic marine organisms