Topics 1-4: contact Hans Bouwmeester
Topic 5: contact Nico van den Brink
MSc Thesis Topics
The thesis topics at the Division of Toxicology are divided in 5 major topics:
1) Risk assessment of herbal food supplements and teas. Contact: Prof. Ivonne Rietjens
2) Mode of action of food-borne (natural) toxins. Contact: Prof. Ivonne Rietjens
3) Alternatives to animal testing. Contact: Dr. Hans Bouwmeester
4) The role of the gut microbiota in the toxicity of food-borne chemicals. Contact: Prof. Ivonne Rietjens
5) Environmental toxicology. Contact: Dr. Nico van den Brink
Please note that apart from the projects given below, there also possibilities for performing a thesis on a risk assessment based on literature studies at the Toxicology department.
Following next you can already find an overview of the different topics for each of the 5 themes:
1) Risk assessment of herbal food supplements and teas.
- Alternative testing strategies to quantify the toxicity of pyrrolizidine alkoloid N-oxides
- Risk assessment of aphrodisiac herbal products from Ghanaian market
- Development of a novel approach for the exposure and risk assessment of human systemic exposure to organophosphate pesticides via food in the Western and Chinese population
2) Mode of action of food-borne (natural) toxins.
- Absorption, metabolism and biological effects of furocoumarins and consequences for their risk assessment
- The role of stability, repair and mutagenicity in the relative hazards and risks of DNA adducts formed by food-borne liver carcinogens of variable carcinogenic potential
- Mode of action-based risk assessment of combined exposure to mycotoxins in maize and maize products
- In vitro metabolism and genotoxicity of naked versus alkylated PAH that may be present in mineral oils
3) Alternatives to animal testing.
- Alternative testing strategies for characterising the development toxicity of different types of polycyclic aromatic hydrocarbons (PAHs) present in petroleum substances
- Role of substituted Polycyclic Aromatic Hydrocarbons in Developmental Toxicity of Petroleum Substances
- Novel testing strategies within the framework of REACH for characterising the developmental toxicity of different types of pollycyclic aromatic hydrocarbons (PAHs) preent in petroleum substances
- Predicting in vivo toxicity by combining in vitro testing and generic physiologically based kinetic (PBK) modelling approach
- Non-animal testing of human risk of plastic associated chemicals
- Evaltuate potential effects of nanamedicine or nanobiomaterials released from Advanced Therapy Medicinal Products and/or Medical Devices
- Development of combined in vitro-in silico methods for the risk assessment of pesticide mixtures
- Novel in vitro assays that enable incorporation of urinary and biliary excretion in generic physologically based kinetic (PBK) models
- Assasment of phospho-signaling in retinal tissues in vitro and in vivo by kinase activity profiling
- Towards next generation risk assesment to inform human-relevant safe levels of chemical exposure: integrated in vitro-in silico approaches for chemicals with putative (anti)androgenic effects
- Effect of exposure to xenobiotics on bile acid composition and its consequences along the intentine-livir-axis
4) The role of gut microbiota in the toxicity of food-borne chemicals.
- Alternative testing stategies for elucidating the metabolic capacity of the intestinal microbiome
- Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
- The role of the gut microbiota in the toxicity and risk assessment of food-borne chemicals
- The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone
- Development of a novel, interdiciplinary model to study interactions between foodborne xenobiotics, the intestinal microbiome and the intestinal epithelium
- Influence of intestinal microbial metabolism on the biological activity of flavonoids from herbel teas and Traditional Chinese Medicine (TCM)
- The effects of food contaminants on gut microbiota and host plasma metabolomics and related health effects
5) Environmental toxicology.
- Interactive effect of exposure to low levels of nanomaterials on the toxicity of environmental chemicals
- Oxidative stress effects of heavy metals on the length of telomeres
- Occurrence of resistance genes in small mammals in agricultural areas
- Effects of lead on immune status of waterfowl and implications for dispersion of avian influenza
- Development of PBK mode for pesticides/metals in small mammals
- Effects of exposure scenarios on the toxicity of environmental contaminants on benthic marine organisms