This group focuses on investigating and exploiting genetic variation and biodiversity. It develops and employs various genetic and genomic technologies (including motif directed profiling) to assess biodiversity between and within species, focusing on genetic variation at the allelic level.
Developing technologies for high throughput analysis is another point of attention. Structure and inheritance of the genetic variation is studied using genetic marker maps and through haplotype reconstruction. The study of neutral genetic variation is used in phylogenetic studies and for quantification of dispersal and gene flow.
Key focus area's
The study of functional diversity includes allelic variation for various quality and resistance traits and for the occurrence of allergens (PR10 proteins in apple and birch, gluten protein families in wheat).
Breeding for varieties with reduced allergenicity
In the Western society, prevalence and severity of allergies are rapidly increasing. Our research focus is on solutions for allergy-related matters in the pre-medical stage. We study the diversity of allergens in germplasm, and develop strategies to lower the amount of allergens by breeding. In this way we aim to prevent rather than cure.
Using molecular markers in breeding: ornamentals catch upActa Horticulturae 1283 (2020). - ISSN 0567-7572 - p. 49 - 53.
Detection of novel QTLs for late blight resistance derived from the wild potato species Solanum microdontum and Solanum pampasenseGenes 11 (2020)7. - ISSN 2073-4425 - p. 1 - 18.
The origin and widespread occurrence of Sli-based self-compatibility in potatoTheoretical and Applied Genetics 133 (2020). - ISSN 0040-5752 - p. 2713 - 2728.
CRISPR/Cas9 Gene Editing of Gluten in Wheat to Reduce Gluten Content and Exposure—Reviewing Methods to Screen for Coeliac SafetyFrontiers in Nutrition 7 (2020). - ISSN 2296-861X
Polynucleotide constructs and methods of gene editing using CPF1Octrooinummer: WO2019238772, gepubliceerd: 2019-12-19.
Green Plant Biotechnology at workWageningen : Groen Kennisnet
Some thoughts on how to use markers in tetraploid rose breedingActa Horticulturae 1232 (2019). - ISSN 0567-7572 - p. 1 - 6.
Kan coeliakiepatiënt straks weer gewoon eten? Tarwe met veilige glutenKan coeliakiepatiënt straks weer gewoon eten? Tarwe met veilige gluten, Resource 13(2019)11 p. 10, 2019-01-21, Albert Sikkema, https://edepot.wur.nl/469823
Tracking disease resistance deployment in potato breeding by enrichment sequencingPlant Biotechnology Journal 17 (2019)2. - ISSN 1467-7644 - p. 540 - 549.
Omics analyses of potato plant materials using an improved one-class classification tool to identify aberrant compositional profiles in risk assessment proceduresFood Chemistry 292 (2019). - ISSN 0308-8146 - p. 350 - 358.
- Johan Willemsen
- Manos Domazakis
- Aurelie Jouanin
- Aviv Andriani
- Carolina Aguilera Galvez
- Xiao Lin
- Yerisf Torres Ascurra
- Xinfang Wang
- Thijs van Dijk
- Daniel Danial
- Angela Machacilla
- Bjarne Larsen
- Giorgio Tumino
- Reinhafd Simon