The research aims to use bacteria to produce biobased chemicals from renewable resources. The focus lies on thermophilic Gram-positives as production platforms.
This group of relatively-unexplored thermophiles has many relevant characteristics that make them attractive as a production organism for green chemicals. Genetic tools-development is required to facilitate high-throughput engineering. The scientific challenge lies in exploring and exploiting the microbial physiology of the selected production organisms. An integrated approach, involving various disciplines, for developing cell factories is anticipated. Successful development of such Bacterial Cell Factories is crucial for establishing the biobased economy.