Advancing polymeric nanotechnology for functional improvements. From Particles to Purpose

Nanomedicine aims to improve diagnosis and treatment by using extremely small particles to deliver medical functions more precisely, but its use in the clinic is still limited by issues such as stability, reliability, and large-scale production. This thesis focuses on developing safe and reliable polymer-based nanoparticles that can be used for medical imaging and therapy. The work demonstrates that these nanoparticles can remain stable over long periods, can be adapted for advanced imaging techniques, and can respond to biological conditions such as acidity. In addition, the particles can be modified to recognize specific disease markers and to support gene-based therapies. Finally, this thesis highlights the importance of careful documentation, standardized methods, and reproducible workflows to ensure that nanomedicine research can be translated into real clinical applications.