Mitochondrial and NAD+ metabolism in aging-related atrial fibrillation and cardiac dysfunction

Heart diseases that become more common with aging, such as atrial fibrillation (AF) and heart failure, are a growing global problem. As the heart ages, its energy-producing parts (mitochondria) and overall metabolism become less efficient, but how these changes lead to irregular heart rhythms and reduced heart function is not fully understood. A key factor is the decline of a molecule called NAD+, which is important for energy production and maintaining cell balance. Therefore, increasing NAD+ levels may help improve heart health during aging. However, we still need to better understand how effective this approach is and what its limitations might be.
My PhD research gains insight into how age-related changes contribute to AF and reduced heart function, and explores potential therapeutic approaches targeting NAD+ metabolism. This research helps identify new ways to prevent or slow down heart diseases and may support the development of future treatments for aging-related heart conditions.